Evidence map›Paper›PMID 26807433›Full record

ArticleCellular and molecular gastroenterology and hepatology2016

Reduction of p53 by knockdown of the

Miao Liu, Shujuan Chen, Mei-Fei Yueh, Guangji Wang, Haiping Hao, Robert H Tukey

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular gastroenterology and hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Ubiquitin-specific protease 7 downregulation suppresses breast cancer in vitro.Turkish journal of biology = Turk biyoloji dergisi · 2020
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Miao LiuLaboratory of Environmental Toxicology, Department of Chemistry & Biochemistry and Pharmacology, UCSD, La Jolla, CA, 92023; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China, 210009.
Shujuan ChenLaboratory of Environmental Toxicology, Department of Chemistry & Biochemistry and Pharmacology, UCSD, La Jolla, CA, 92023.
Mei-Fei YuehLaboratory of Environmental Toxicology, Department of Chemistry & Biochemistry and Pharmacology, UCSD, La Jolla, CA, 92023.
Guangji WangKey Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China, 210009.
Haiping HaoKey Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China, 210009.
Robert H TukeyLaboratory of Environmental Toxicology, Department of Chemistry & Biochemistry and Pharmacology, UCSD, La Jolla, CA, 92023.
University of California, San Diego · USChina Pharmaceutical University · CNState Key Laboratory of Natural Medicine

Funding

Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
Xenobiotic sensors PXR and CAR and regulation of the UGT1 locusR01GM086713 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2009 to 2017
$2.6M
Neonatal hyperbilirubinemia in a humanized UGT1 animal modelR01GM100481 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2012 to 2015
$1.3M
Organ-specific Ugt1 profiling in detoxifying the anticancer drug CPT-11R21CA171008 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHUJUAN · 2012 to 2013
$361k
NCI NIH HHS R21 CA171008NIEHS NIH HHS P42 ES010337NIGMS NIH HHS R01 GM086713NIGMS NIH HHS R01 GM100481
6 · The paper itself

Abstract

BACKGROUND &

aimsThe UDP-glucuronosyltransferases (UGTs) are part of the cells machinery that protects the tissues from a toxicant insult by environmental and host cell metabolites. We have investigated the mechanism behind tumor growth and UGT repression.

methodsWe initially silenced the

resultsKnockdown of the UGT1A proteins by RNAi in human colon cancer cells and knockout of the

conclusionsOur results demonstrate that UGT1A expression is required to maintain and sustain p53 activation in stress-induced colon epithelial cells and has a significant impact on p53-mediated apoptosis and tumor suppression, thus protecting the colon tissue from neoplastic transformation.

Indexed as

apoptosiscolon cancerER stressUGT1A

Identifiers

PMID26807433
PMCPMC4721636
OpenAlexW2127573043

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.