Evidence map›Paper›PMID 26807384›Full record

ReviewJournal of clinical and translational hepatology2015

The Role of Immune Cells in Chronic HBV Infection.

Hai-Jun Li, Nai-Cui Zhai, Hong-Xiao Song, Yang Yang, An Cui, Tian-Yang Li, Zheng-Kun Tu

Abstract readReview
In one paragraph

Review in Journal of clinical and translational hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Circulating IL-1Journal of immunology research · 2022
    Article
  11. Review
  12. Article
  13. Hepatitis B e Antigen Induces NKG2AFrontiers in cell and developmental biology · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. [Establishment of a cell co-culture system in accordance with the immunological characteristics of chronic HBV infection].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2016
    Article
  18. [A study of immune response to HBsAg mediated by CD4+ memory T lymphocytes in immunized HBV transgenic mice].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2016
    Article
  19. Article
  20. [Association between interleukin-18 gene polymorphisms and hepatocellular carcinoma caused by hepatitis B virus].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hai-Jun LiDepartment of Translational Medicine, The First Hospital, Jilin University, Changchun, Jilin, China.
Nai-Cui ZhaiDepartment of Translational Medicine, The First Hospital, Jilin University, Changchun, Jilin, China.
Hong-Xiao SongDepartment of Translational Medicine, The First Hospital, Jilin University, Changchun, Jilin, China.
Yang YangDepartment of Translational Medicine, The First Hospital, Jilin University, Changchun, Jilin, China.
An CuiDepartment of Translational Medicine, The First Hospital, Jilin University, Changchun, Jilin, China.
Tian-Yang LiDepartment of Translational Medicine, The First Hospital, Jilin University, Changchun, Jilin, China.
Zheng-Kun TuDepartment of Translational Medicine, The First Hospital, Jilin University, Changchun, Jilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases that may progress to liver cirrhosis and hepatocellular carcinoma. Host immune responses are important factors that determine whether HBV infection is cleared or persists. After infection, viral replication occurs inside hepatocytes, and the secretion of infectious virions can take place at high rates for decades. Consequently, HBV DNA and viral proteins, like HBV early antigen (HBeAg) and HBV surface antigen (HBsAg), can be easily detected in serum. Chronic infection with HBV is the result of an ineffective antiviral immune response towards the virus. In this review, we discuss the role of immune cells in chronic HBV infection.

Indexed as

CD8+ T cellsHepatitis B virusImmune cellsNatural killer cells

Identifiers

PMID26807384
PMCPMC4721896

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.