Evidence map›Paper›PMID 26807369›Full record

ReviewQuantitative imaging in medicine and surgery2015

T1ρ magnetic resonance: basic physics principles and applications in knee and intervertebral disc imaging.

Yì-Xiáng J Wáng, Qinwei Zhang, Xiaojuan Li, Weitian Chen, Anil Ahuja, Jing Yuan

Abstract readReview
In one paragraph

Review in Quantitative imaging in medicine and surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. TNMR in biomedicine · 2026
    Article
  2. Metabolomics: A Viable Approach to Understand the Pathogenesis of Reactive ArthritisEndocrine, metabolic & immune disorders drug targets · 2026
    Review
  3. Article
  4. Review
  5. [EJNMMI research · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Quantitative susceptibility and T1Osteoarthritis and cartilage open · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Alternating Look-Locker for quantitative TMagnetic resonance in medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yì-Xiáng J Wáng1 Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China ; 2 Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands ; 3 Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA ; 4 Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong SAR, China.
Qinwei Zhang1 Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China ; 2 Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands ; 3 Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA ; 4 Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong SAR, China.
Xiaojuan Li1 Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China ; 2 Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands ; 3 Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA ; 4 Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong SAR, China.
Weitian Chen1 Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China ; 2 Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands ; 3 Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA ; 4 Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong SAR, China.
Anil Ahuja1 Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China ; 2 Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands ; 3 Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA ; 4 Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong SAR, China.
Jing Yuan1 Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China ; 2 Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands ; 3 Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA ; 4 Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong SAR, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T1ρ relaxation time provides a new contrast mechanism that differs from T1- and T2-weighted contrast, and is useful to study low-frequency motional processes and chemical exchange in biological tissues. T1ρ imaging can be performed in the forms of T1ρ-weighted image, T1ρ mapping and T1ρ dispersion. T1ρ imaging, particularly at low spin-lock frequency, is sensitive to B0 and B1 inhomogeneity. Various composite spin-lock pulses have been proposed to alleviate the influence of field inhomogeneity so as to reduce the banding-like spin-lock artifacts. T1ρ imaging could be specific absorption rate (SAR) intensive and time consuming. Efforts to address these issues and speed-up data acquisition are being explored to facilitate wider clinical applications. This paper reviews the T1ρ imaging's basic physic principles, as well as its application for cartilage imaging and intervertebral disc imaging. Compared to more established T2 relaxation time, it has been shown that T1ρ provides more sensitive detection of proteoglycan (PG) loss at early stages of cartilage degeneration. T1ρ has also been shown to provide more sensitive evaluation of annulus fibrosis (AF) degeneration of the discs.

Indexed as

biomarkercartilagedegenerationintervertebral discmusculoskeletal systemosteoarthritis (OA)quantitativeT1ρ

Identifiers

PMID26807369
PMCPMC4700236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.