Evidence map›Paper›PMID 26807233›Full record

ArticleMolecular and clinical oncology2015

Endothelial protein C receptor gene 6936A/G single-nucleotide polymorphism as a possible biomarker of thrombotic risk in acute myeloid leukemia.

Samaher Besbes, Hamda Althawadi, Halema Alfarsi, Shahsoltan Mirshahi, Ruoping Tang, Fanny Fava, Julia Pardo, Eva-Maria Huessler, Thomas Galtier, Ibtissem Ghedira and 3 more

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In one paragraph

Article in Molecular and clinical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Novel Association of Thrombophilic PROS1, PROC and CPB2 Genes Polymorphisms with Recurrent Spontaneous Miscarriage Women in Jordan.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Samaher BesbesUMR, Paris Diderot, Paris 7 University, Lariboisière Hospital, INSERM U965, 75010 Paris, France.
Hamda AlthawadiUMR, Paris Diderot, Paris 7 University, Lariboisière Hospital, INSERM U965, 75010 Paris, France; Qatar Foundation, Doha 5825, Qatar.
Halema AlfarsiUMR, Paris Diderot, Paris 7 University, Lariboisière Hospital, INSERM U965, 75010 Paris, France; Qatar Foundation, Doha 5825, Qatar.
Shahsoltan MirshahiResearch and Development, Diagnostica Stago, 92230 Gennevilliers, France.
Ruoping TangLeukemia Tumor Bank, Saint-Antoine Hospital, 75012 Paris, France.
Fanny FavaLeukemia Tumor Bank, Saint-Antoine Hospital, 75012 Paris, France.
Julia PardoUMR, Paris Diderot, Paris 7 University, Lariboisière Hospital, INSERM U965, 75010 Paris, France.
Eva-Maria HuesslerUMRS 872, Information Sciences to Support Personalized Medicine Group, Cordeliers Research Center, 75006 Paris, France.
Thomas GaltierUMRS 872, Information Sciences to Support Personalized Medicine Group, Cordeliers Research Center, 75006 Paris, France.
Ibtissem GhediraUniversity of Monastir, Monastir 5000, Tunisia.
Jeannette SoriaUMR, Paris Diderot, Paris 7 University, Lariboisière Hospital, INSERM U965, 75010 Paris, France.
Jean Pierre MarieLeukemia Tumor Bank, Saint-Antoine Hospital, 75012 Paris, France.
Massoud MirshahiUMR, Paris Diderot, Paris 7 University, Lariboisière Hospital, INSERM U965, 75010 Paris, France.
Délégation Paris 7 · FRCentre de Recherche des Cordeliers · FRHôpital Saint-Antoine · FRInserm · FRSorbonne Université · FRStago (France) · FRUniversité Paris Cité · FRUniversity of Monastir · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein C (PC) is a natural anticoagulant, which interacts with the endothelial PC receptor (EPCR). EPCR single-nucleotide polymorphism (SNP) 6936A/G results in high levels of a free soluble form of EPCR (sEPCR) and may affect the risk of coagulation. The objective of this study was to assess whether the 6936A/G SNP of the EPCR gene is involved in the procoagulant activity displayed by hematological malignancies. EPCR 6936A/G polymorphism analysis was performed in 205 patients with hematological malignancies and in 63 healthy controls. All the subjects were genotyped for the EPCR 6936A/G SNP (AA, AG and GG genotypes). The 6936A/G polymorphism distribution was similar between healthy donors and patients. The association between EPCR 6936A/G SNP and thrombosis was investigated in 110 patients. The disease-wise break-up revealed that 55 of the patients suffered from acute myeloid leukemia (AML). In AML patients, the incidence of thrombosis was 28.3% and significantly higher in the 6936AG compared with that in the 6936AA genotype (50 vs. 22%, respectively). In conclusion, this study revealed a significant association of the 6936AG genotype of EPCR with thrombotic events in AML. Therefore, the presence of the 6936AG genotype in AML patients may be considered as a risk indicator of thrombosis.

Indexed as

6936A/G single-nucleotide polymorphismacute myeloid leukemiaendothelial protein C receptor genegenetic diagnosisthrombosis

Identifiers

PMID26807233
PMCPMC4665720
OpenAlexW1820591913

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.