ArticleAmerican journal of translational research2015
Regulation of β-catenin-mediated esophageal cancer growth and invasion by miR-214.
Article in American journal of translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- MiR-214-3p targets Ras-related protein 14 (RAB14) to inhibit cellular migration and invasion in esophageal Cancer cells.BMC cancer · 2022Article
- Roles of Wnt/β-catenin signaling pathway related microRNAs in esophageal cancer.World journal of clinical cases · 2022Review
- miR-214 Modulates the Growth and Migration of Oral Cancer before and after Chemotherapy through Mediating ULK1.Journal of immunology research · 2022Article
- The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy.Biomarker research · 2021Review
- LncRNA HOTAIR promotes proliferation and inhibits apoptosis by sponging miR-214-3p in HPV16 positive cervical cancer cells.Cancer cell international · 2021Article
- SOX2-Upregulated microRNA-30e Promotes the Progression of Esophageal Cancer via Regulation of the USP4/SMAD4/CK2 Axis.Molecular therapy. Nucleic acids · 2021Article
- MicroRNA-214-3p Targeting Ctnnb1 Promotes 3T3-L1 Preadipocyte Differentiation by Interfering with the Wnt/β-Catenin Signaling Pathway.International journal of molecular sciences · 2019Article
- Long Noncoding RNA GAS5 Promotes Proliferation, Migration, and Invasion by Regulation of miR-301a in Esophageal Cancer.Oncology research · 2018Article
- LncRNA PVT1 promotes ovarian cancer progression by silencing miR-214.Cancer biology & medicine · 2018Article
- Knockdown of TGIF attenuates the proliferation and tumorigenicity of EC109 cells and promotes cisplatin-induced apoptosis.Oncology letters · 2017Article
- Long Noncoding RNA LINC0086 Functions as a Tumor Suppressor in Nasopharyngeal Carcinoma by Targeting miR-214.Oncology research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The malignancy of esophageal cancer (EC) is largely due to its fast growth and invasion, in which WNT/β-catenin signaling plays a critical role. Hence, suppression of β-catenin signal transduction in EC cells may inhibit cancer growth and metastases. Among all microRNAs (miRNAs), miR-214 has been shown as a tumor suppressor in many cancers, but has yet studied in EC. Here we found that EC specimens had significant higher levels of β-catenin, and significantly lower levels of miR-214, compared to paired non-EC tissue. The levels of β-catenin and miR-214 were inversely correlated in EC specimens. Bioinformatics analyses showed that miR-214 bound to 3'-UTR of β-catenin mRNA in EC cells to inhibit its translation. Overexpression of miR-214 decreased β-catenin protein, while depletion of miR-214 increased β-catenin protein in EC cells, without altering β-catenin mRNA levels. Overexpression of miR-214 in EC cells inhibited cell growth and invasion, while depletion of miR-214 in EC lines increased cell growth and invasion. Taken together, our data demonstrate a previously unappreciated role for miR-214 in suppression of β-catenin-mediated EC cell growth and invasion, and highlight miR-214 as a potent suppressor of EC.
Indexed as
Identifiers
26807179PMC4697711W2416297225What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.