Evidence map›Paper›PMID 26807054›Full record

ArticleJournal of the Medical Library Association : JMLA2016

Evaluation of popular drug information resources on clinically useful and actionable pharmacogenomic information.

Jennifer S Chang, Duyen-Anh Pham, Maithao T Dang, Yiting Lu, Sheri VanOsdol, Jaekyu Shin

Abstract readEvaluation Study
In one paragraph

Article in Journal of the Medical Library Association : JMLA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Tertiary drug information sources for treatment and prevention of COVID-19.Journal of the Medical Library Association : JMLA · 2023
    Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jennifer S Chang
Duyen-Anh Pham
Maithao T Dang
Yiting Lu
Sheri VanOsdol
Jaekyu Shin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPharmacogenomics is the study of how genes affect a person's response to drugs. This descriptive study assessed whether popular drug information resources provide clinically useful pharmacogenomic (PGx) information.

methodsFour resources (package inserts, Lexicomp, Micromedex 2.0, and Epocrates) were evaluated for information about twenty-seven drugs.

resultsThere was wide variability of PGx information. Whereas Lexicomp included relevant PGx biomarker information for all 27 drugs, Epocrates did in less than 50% of the drugs. None of the resources had monographs that fully incorporated Clinical Pharmacogenomics Implementation Consortium (CPIC) recommendations in more than 30% of the drugs.

conclusionLexicomp appears to be most useful PGx drug information resource, but none of the resources are sufficient.

Indexed as

Databases as TopicDatabases, FactualDrug Information ServicesHumansPharmacogeneticsSensitivity and SpecificityBiomarkersDrug Information ServicesGenetic TestingPharmacogenomics

Identifiers

PMID26807054
PMCPMC4722644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.