Evidence map›Paper›PMID 26807042›Full record

ArticleProceedings. Mathematical, physical, and engineering sciences2015

Verification of cardiac mechanics software: benchmark problems and solutions for testing active and passive material behaviour.

Sander Land, Viatcheslav Gurev, Sander Arens, Christoph M Augustin, Lukas Baron, Robert Blake, Chris Bradley, Sebastian Castro, Andrew Crozier, Marco Favino and 21 more

Abstract read
In one paragraph

Article in Proceedings. Mathematical, physical, and engineering sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Review
  2. Article
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  5. Article
  6. Review
  7. Numerical accuracy of closed-loop steady state in a zero-dimensional cardiovascular model.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Article
  8. Article
  9. In-silico heart model phantom to validate cardiac strain imaging.bioRxiv : the preprint server for biology · 2024
    Article
  10. Guidelines for mechanistic modeling and analysis in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  11. A Modular Framework for Implicit 3D-0D Coupling in Cardiac Mechanics.Computer methods in applied mechanics and engineering · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
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  19. Bayesian optimisation for efficient parameter inference in a cardiac mechanics model of the left ventricle.International journal for numerical methods in biomedical engineering · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Sander LandDepartment of Biomedical Engineering, King's College London , London, UK.ORCID 0000-0001-8572-251X
Viatcheslav GurevThomas J. Watson Research Center, IBM Research, Yorktown Heights , NY 10598, USA.
Sander ArensDepartment of Physics and Astronomy , Ghent University , Ghent, Belgium.
Christoph M AugustinInstitute of Biophysics, Medical University of Graz , Graz, Austria.
Lukas BaronInstitute of Biomedical Engineering, Karlsruhe Institute of Technology , Karlsruhe, Germany.
Robert BlakeDepartment of Biomedical Engineering and Institute for Computational Medicine , Johns Hopkins University , Baltimore, MD 21218, USA.
Chris BradleyAuckland Bioengineering Institute, University of Auckland , Auckland, New Zealand.
Sebastian CastroDepartment of Structural and Geotechnical Engineering , Pontifica Universidad Católica de Chile , Chile.
Andrew CrozierInstitute of Biophysics, Medical University of Graz , Graz, Austria.
Marco FavinoCenter for Computational Medicine in Cardiology , Institute of Computational Science, Università della Svizzera italiana , Lugano, Switzerland.
Thomas E FastlDepartment of Biomedical Engineering, King's College London , London, UK.
Thomas FritzInstitute of Biomedical Engineering, Karlsruhe Institute of Technology , Karlsruhe, Germany.
Hao GaoSchool of Mathematics and Statistics, University of Glasgow , Glasgow, UK.
Alessio GizziDepartment of Engineering, Nonlinear Physics and Mathematical Modeling Lab , University Campus Bio-Medico of Rome , Rome, Italy.
Boyce E GriffithInterdisciplinary Applied Mathematics Center , University of North Carolina at Chapel Hill , Chapel Hill, NC, USA.
Daniel E HurtadoDepartment of Structural and Geotechnical Engineering , Pontifica Universidad Católica de Chile , Chile.
Rolf KrauseCenter for Computational Medicine in Cardiology , Institute of Computational Science, Università della Svizzera italiana , Lugano, Switzerland.
Xiaoyu LuoSchool of Mathematics and Statistics, University of Glasgow , Glasgow, UK.
Martyn P NashAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand; Department of Engineering Science, University of Auckland, Auckland, New Zealand.
Simone PezzutoCenter for Computational Medicine in Cardiology, Institute of Computational Science, Università della Svizzera italiana, Lugano, Switzerland; Simula Research Laboratory, Fornebu, Norway.
Gernot PlankInstitute of Biophysics, Medical University of Graz , Graz, Austria.
Simone RossiCivil and Environmental Engineering Department , Duke University , Durham, NC 27708-0287, USA.
Daniel RuprechtCenter for Computational Medicine in Cardiology , Institute of Computational Science, Università della Svizzera italiana , Lugano, Switzerland.
Gunnar SeemannInstitute of Biomedical Engineering, Karlsruhe Institute of Technology , Karlsruhe, Germany.
Nicolas P SmithDepartment of Biomedical Engineering, King's College London, London, UK; Department of Engineering Science, University of Auckland, Auckland, New Zealand.
Joakim SundnesSimula Research Laboratory , Fornebu, Norway.
J Jeremy RiceThomas J. Watson Research Center, IBM Research, Yorktown Heights , NY 10598, USA.
Natalia TrayanovaDepartment of Biomedical Engineering and Institute for Computational Medicine , Johns Hopkins University , Baltimore, MD 21218, USA.
Dafang WangDepartment of Biomedical Engineering and Institute for Computational Medicine , Johns Hopkins University , Baltimore, MD 21218, USA.
Zhinuo Jenny WangAuckland Bioengineering Institute, University of Auckland , Auckland, New Zealand.
Steven A NiedererDepartment of Biomedical Engineering, King's College London , London, UK.

Funding

System Biology Center in New YorkP50GM071558 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI IYENGAR, SRINIVAS RAVI V · 2007 to 2017
$22.8M
Mathematical modeling and computer simulation of aortic dissectionR01HL117063 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GRIFFITH, BOYCE EUGENE · 2013 to 2017
$2.3M
British Heart Foundation PG/14/64/31043NHLBI NIH HHS R01 HL117063NIGMS NIH HHS P50 GM071558
6 · The paper itself

Abstract

Models of cardiac mechanics are increasingly used to investigate cardiac physiology. These models are characterized by a high level of complexity, including the particular anisotropic material properties of biological tissue and the actively contracting material. A large number of independent simulation codes have been developed, but a consistent way of verifying the accuracy and replicability of simulations is lacking. To aid in the verification of current and future cardiac mechanics solvers, this study provides three benchmark problems for cardiac mechanics. These benchmark problems test the ability to accurately simulate pressure-type forces that depend on the deformed objects geometry, anisotropic and spatially varying material properties similar to those seen in the left ventricle and active contractile forces. The benchmark was solved by 11 different groups to generate consensus solutions, with typical differences in higher-resolution solutions at approximately 0.5%, and consistent results between linear, quadratic and cubic finite elements as well as different approaches to simulating incompressible materials. Online tools and solutions are made available to allow these tests to be effectively used in verification of future cardiac mechanics software.

Indexed as

benchmarkcardiac mechanicsverificationVVUQ

Identifiers

PMID26807042
PMCPMC4707707

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.