ArticleBiophysical journal2016
Molecular Order of Arterial Collagen Using Circular Polarization Second-Harmonic Generation Imaging.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Diffraction order-engineered polarization-dependent silicon nano-antennas metagrating for compact subtissue Mueller microscopy.Nanophotonics (Berlin, Germany) · 2025Article
- Second harmonic generation imaging reveals entanglement of collagen fibers in the elephant trunk skin dermis.Communications biology · 2025Article
- Strain-dependent dynamic re-alignment of collagen fibers in skeletal muscle extracellular matrix.Acta biomaterialia · 2024Article
- Metasurface-Enabled 3-in-1 Microscopy.ACS photonics · 2023Article
- Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue.NPJ Regenerative medicine · 2023Article
- Label-Free Multiphoton Microscopy: Much More Than Fancy Images.International journal of molecular sciences · 2021Review
- Second harmonic generation characterization of collagen in whole bone.Biomedical optics express · 2020Article
- Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load.Science advances · 2019Article
- Micromechanics of elastic lamellae: unravelling the role of structural inhomogeneity in multi-scale arterial mechanics.Journal of the Royal Society, Interface · 2018Article
- Quantitative second harmonic generation microscopy for the structural characterization of capsular collagen in thyroid neoplasms.Biomedical optics express · 2018Article
- μMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure.Scientific reports · 2017Article
- Imaging Collagen in Scar Tissue: Developments in Second Harmonic Generation Microscopy for Biomedical Applications.International journal of molecular sciences · 2017Review
- Glycosaminoglycans contribute to extracellular matrix fiber recruitment and arterial wall mechanics.Biomechanics and modeling in mechanobiology · 2017Article
- Detecting ordered small molecule drug aggregates in live macrophages: a multi-parameter microscope image data acquisition and analysis strategy.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Second-harmonic generation (SHG) originates from the interaction between upconverted fields from individual scatterers. This renders SHG microscopy highly sensitive to molecular distribution. Here, we aim to take advantage of the difference in SHG between aligned and partially aligned molecules to probe the degree of molecular order during biomechanical testing, independently of the absolute orientation of the scattering molecules. Toward this goal, we implemented a circular polarization SHG imaging approach and used it to quantify the intensity change associated with collagen fibers straightening in the arterial wall during mechanical stretching. We were able to observe the delayed alignment of collagen fibers during mechanical loading, thus demonstrating a simple method to characterize molecular distribution using intensity information alone.
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Registered trials
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