ArticleScientific reports2016
Acute fluoxetine exposure alters crab anxiety-like behaviour, but not aggressiveness.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Anxiolytic-like effects of acute serotonin-releasing agents in zebrafish models of anxiety: experimental study and systematic review.Acta neuropsychiatrica · 2024Pooled it
- The Role of Social Stress in the Development of Inhibitory Control Deficit: A Systematic Review in Preclinical Models.International journal of environmental research and public health · 2021Pooled it
- A Machine Learning Framework Integrating DeepLabCut and SimBA for Quantifying Aggressive Behavior in Swimming CrabAnimals : an open access journal from MDPI · 2026Article
- Assessing the Welfare of Spiny Lobsters and True Lobsters in Aquaria: Biology-Informed Best-Practice Guidelines for Captive Conditions.Animals : an open access journal from MDPI · 2025Article
- Animal welfare risks from commercial practices involving cephalopod molluscs and decapod crustaceans.Animal welfare (South Mimms, England) · 2025Review
- Electric shock causes a fleeing-like persistent behavioral response in the nematode Caenorhabditis elegans.Genetics · 2023Article
- Article
- Infection with an acanthocephalan helminth reduces anxiety-like behaviour in crustacean host.Scientific reports · 2022Article
- Effect of Animal Stocking Density and Habitat Enrichment on Survival and Vitality of Wild Green Shore Crabs,Animals : an open access journal from MDPI · 2022Article
- Clove Oil-Nanostructured Lipid Carriers: A Platform of Herbal Anesthetics in Whiteleg Shrimp (Foods (Basel, Switzerland) · 2022Article
- Animal sentience.Philosophy compass · 2022Article
- Article
- Short-term exposure to tricyclic antidepressants delays righting time in marine and freshwater snails with evidence for low-dose stimulation of righting speed by imipramine.Environmental science and pollution research international · 2019Article
- Behaviour of freshwater snails (Radix balthica) exposed to the pharmaceutical sertraline under simulated predation risk.Ecotoxicology (London, England) · 2018Article
- Alterations of larval photo-dependent swimming responses (PDR): New endpoints for rapid and diagnostic screening of aquatic contamination.Ecotoxicology and environmental safety · 2018Article
- Shape and size of the arenas affect amphipod behaviours: implications for ecotoxicology.PeerJ · 2018Article
- Anxiety-like behaviour increases safety from fish predation in an amphipod crustacea.Royal Society open science · 2017Article
- Cadmium bioaccumulates after acute exposure but has no effect on locomotion or shelter-seeking behaviour in the invasive green shore crab (Conservation physiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aggression and responsiveness to noxious stimuli are adaptable traits that are ubiquitous throughout the animal kingdom. Like vertebrate animals, some invertebrates have been shown to exhibit anxiety-like behaviour and altered levels of aggression that are modulated by the neurotransmitter serotonin. To investigate whether this influence of serotonin is conserved in crabs and whether these behaviours are sensitive to human antidepressant drugs; the striped shore crab, Pachygrapsus crassipes, was studied using anxiety (light/dark test) and aggression (mirror test) paradigms. Crabs were individually exposed to acute doses of the selective serotonin reuptake inhibitor, fluoxetine (5 or 25 mg/L), commonly known as Prozac®, followed by behavioural testing. The high dose of fluoxetine significantly decreased anxiety-like behaviour but had no impact on mobility or aggression. These results suggest that anxiety-like behaviour is more sensitive to modulation of serotonin than is aggressiveness in the shore crab.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.