ReviewProgress in brain research2016
Competing neurobehavioral decision systems theory of cocaine addiction: From mechanisms to therapeutic opportunities.
Review in Progress in brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Deprivation Has Inconsistent Effects on Delay Discounting: A Review.Frontiers in behavioral neuroscience · 2022Pooled it
- "I's" on the prize: A systematic review of individual differences in Contingency Management treatment response.Journal of substance abuse treatment · 2019Pooled it
- Targeting cortico-striatal-amygdalar networks via theta-band frontoparietal synchronization in opioid use disorder: a randomized tACS-fMRI Trial.Molecular psychiatry · 2026Trial
- A novel method to assess delay discounting indicates greater ambivalence for delayed rewards.Journal of the experimental analysis of behavior · 2026Article
- Behavioral and Functional Neuroimaging Effects of Delivering a Course of Repetitive Transcranial Magnetic Stimulation to Personalized Targets Within the Ventrolateral Or Dorsolateral Prefrontal Cortex in Treatment-Seeking Participants with Cannabis Use Disorder.medRxiv : the preprint server for health sciences · 2026Article
- Frustration brake failure hypothesis of substance use disorders.Frontiers in psychiatry · 2026Article
- Progressing from Simple to Multidimensional Models Towards a Biopsychosocial Framework of Addiction.Current addiction reports · 2026Review
- Article
- Abnormal ventromedial-to-dorsolateral hierarchical topography of striatal circuits in cocaine use disorder and its modulations by brain stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Left ventromedial prefrontal cortex inhibitory rTMS as an anti-stress intervention in opioid use disorder: Trial design.Contemporary clinical trials communications · 2025Article
- Phenylketonuria as an Adherence Disease.Patient preference and adherence · 2025Review
- Longitudinal Associations Among Socioeconomic Status, Delay Discounting, and Substance Use in Adolescence.Journal of youth and adolescence · 2024Article
- Validation of the Sexual Discounting Task for Use in Adolescents.Archives of sexual behavior · 2024Article
- Discriminative functional connectivity signature of cocaine use disorder links to rTMS treatment response.Nature. Mental health · 2024Article
- Medial Prefrontal Cortex Theta Burst Stimulation Improves Treatment Outcomes in Alcohol Use Disorder: A Double-Blind, Sham-Controlled Neuroimaging Study.Biological psychiatry global open science · 2023Article
- How is Patient Adherence Possible? A Novel Mechanistic Model of Adherence Based on Humanities.Patient preference and adherence · 2023Review
- Transcranial Magnetic Stimulation for Long-Term Smoking Cessation: Preliminary Examination of Delay Discounting as a Therapeutic Target and the Effects of Intensity and Duration.Frontiers in human neuroscience · 2022Article
- Electrophysiological predictors and indicators of contingency management treatment response: Rationale and design for the ways of rewarding abstinence project (WRAP).Contemporary clinical trials communications · 2021Article
- Reinforcer pathology in cocaine use disorder: Temporal window determines cocaine valuation.Drug and alcohol dependence · 2021Article
- Neuroanatomical Correlates of Impulsive Choices and Risky Decision Making in Young Chronic Tobacco Smokers: A Voxel-Based Morphometry Study.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cocaine dependence is a difficult-to-treat, chronically relapsing disorder. Multiple scientific disciplines provide distinct perspectives on this disorder; however, connections between disciplines are rare. The competing neurobehavioral decision systems (CNDS) theory posits that choice results from the interaction between two decision systems (impulsive and executive) and that regulatory imbalance between systems can induce pathology, including addiction. Using this view, we integrate a diverse set of observations on cocaine dependence, including bias for immediacy, neural activity and structure, developmental time course, behavioral comorbidities, and the relationship between cocaine dependence and socioeconomic status. From the CNDS perspective, we discuss established and emerging behavioral, pharmacological, and neurological treatments and identify possible targets for future treatments. The ability of the CNDS theory to integrate diverse findings highlights its utility for understanding cocaine dependence and supports that dysregulation between the decision systems contributes to addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.