ArticleScientific reports2016
Biofortified indica rice attains iron and zinc nutrition dietary targets in the field.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
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Who cites it
101 citing papers in PubMed, 342 citations in OpenAlex.
- The effect of zinc-biofortified rice on zinc status of Bangladeshi preschool children: a randomized, double-masked, household-based, controlled trial.The American journal of clinical nutrition · 2022Trial
- CRISPR/Cas-based genome editing for enhancing grain quality traits in rice (Plant signaling & behavior · 2026Review
- Zinc Is Probably Not Accumulated as Zinc Sulfide, and Is Co-Released with Glutathione to the Culture Medium, in the Marine AlgaInternational journal of molecular sciences · 2026Article
- Analysis of the TaNAS gene family in bread wheat identifies additional members and candidates for intragenic biofortification.Journal of experimental botany · 2026Article
- Agronomic Biofortification Strategies to Increase Grain Zinc Concentrations of Wheat, Rice and Maize: A Systematic Review and Network-Meta-Analysis.Campbell systematic reviews · 2026Review
- From paddy soil to dining table: biological biofortification of rice with zinc.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- Agronomic biofortification in crops with Zn: the zinc-iron interaction dilemma.Frontiers in plant science · 2026Review
- Toward Nutrient-Rich Rice: Biofortification through Mineral Accumulation and Low Phytic Acid Content.Journal of agricultural and food chemistry · 2025Article
- Zinc-solubilizing bacterial consortia: a promising approach for zinc biofortification of crops.Frontiers in microbiology · 2025Review
- Biofortification: Future Challenges for a Newly Emerging Technology to Improve Nutrition Security Sustainably.Current developments in nutrition · 2024Article
- Improving Rice Grain Quality Through Ecotype Breeding for Enhancing Food and Nutritional Security in Asia-Pacific Region.Rice (New York, N.Y.) · 2024Review
- Biofortification of Plant- and Animal-Based Foods in Limiting the Problem of Microelement Deficiencies-A Narrative Review.Nutrients · 2024Review
- Genetic biofortification: advancing crop nutrition to tackle hidden hunger.Functional & integrative genomics · 2024Review
- Multiple mutations inJournal of genetics · 2024Article
- Quantitative trait loci for grain mineral element accumulation in Vietnamese rice landraces.PloS one · 2024Article
- Functional nutritional rice: current progresses and future prospects.Frontiers in plant science · 2024Review
- An integration of genome-wide survey, homologous comparison and gene expression analysis provides a basic framework for the ZRT, IRT-like protein (ZIP) in foxtail millet.Frontiers in plant science · 2024Article
- Genetic dissection of maize (Zea maysL.) trace element traits using genome-wide association studies.BMC plant biology · 2023Article
- Implications of ZnO Nanoparticles and S-Nitrosoglutathione on Nitric Oxide, Reactive Oxidative Species, Photosynthetic Pigments, and Ionomic Profile in Rice.Antioxidants (Basel, Switzerland) · 2023Article
- Nicotianamine: A Key Player in Metal Homeostasis and Hyperaccumulation in Plants.International journal of molecular sciences · 2023Review
41 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 10 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More than two billion people are micronutrient deficient. Polished grains of popular rice varieties have concentration of approximately 2 μg g(-1) iron (Fe) and 16 μg g(-1) zinc (Zn). The HarvestPlus breeding programs for biofortified rice target 13 μg g(-1) Fe and 28 μg g(-1) Zn to reach approximately 30% of the estimated average requirement (EAR). Reports on engineering Fe content in rice have shown an increase up to 18 μg g(-1) in glasshouse settings; in contrast, under field conditions, 4 μg g(-1) was the highest reported concentration. Here, we report on selected transgenic events, field evaluated in two countries, showing 15 μg g(-1) Fe and 45.7 μg g(-1) Zn in polished grain. Rigorous selection was applied to 1,689 IR64 transgenic events for insert cleanliness and, trait and agronomic performances. Event NASFer-274 containing rice nicotianamine synthase (OsNAS2) and soybean ferritin (SferH-1) genes showed a single locus insertion without a yield penalty or altered grain quality. Endosperm Fe and Zn enrichment was visualized by X-ray fluorescence imaging. The Caco-2 cell assay indicated that Fe is bioavailable. No harmful heavy metals were detected in the grain. The trait remained stable in different genotype backgrounds.
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