ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2016
Endogenous sex hormones and cognitive function in older women.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Associations between cognitive function and endogenous levels of estradiol and testosterone in adults with type 2 diabetes.Journal of diabetes and its complications · 2022Trial
- Prospective study of reproductive span and menopausal hormone therapy and cognitive decline over 8 years in the Nurses' Health Study.Menopause (New York, N.Y.) · 2026Article
- Three-stage sequential targeted nasal drops for correcting abnormal mitochondrial division in microglia.Bioactive materials · 2025Article
- Associations between blood sex hormones, cognitive decline and incident dementia in community-dwelling older Australian women: a prospective cohort study.Climacteric : the journal of the International Menopause Society · 2025Article
- Endogenous Estrogens and Brain Activation During Verbal Memory Encoding and Recognition in the Postmenopause.The Journal of clinical endocrinology and metabolism · 2025Article
- Association between serum estradiol levels and cognitive function in older women: a cross-sectional analysis.Frontiers in aging neuroscience · 2024Article
- Associations of Bioavailable Serum Testosterone With Cognitive Function in Older Men: Results From the National Health and Nutrition Examination Survey.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Reproductive Markers in Alzheimer's Disease Progression: The Framingham Heart Study.The journal of prevention of Alzheimer's disease · 2023Article
- Longitudinal evaluation of dehydroepiandrosterone (DHEA), its sulfated form and estradiol with cancer-related cognitive impairment in early-stage breast cancer patients receiving chemotherapy.Scientific reports · 2022Article
- Association of reproductive factors with dementia: A systematic review and dose-response meta-analyses of observational studies.EClinicalMedicine · 2022Article
- Low Serum Testosterone Concentrations Are Associated With Poor Cognitive Performance in Older Men but Not Women.Frontiers in aging neuroscience · 2021Article
- Positive Effect of Cognitive Reserve on Episodic Memory, Executive and Attentional Functions Taking Into Account Amyloid-Beta, Tau, and Apolipoprotein E Status.Frontiers in aging neuroscience · 2021Article
- Sexual dimorphism in cognitive disorders in a murine model of neuropathic pain.Behavioral and brain functions : BBF · 2020Article
- Impact of adrenal hormones, reproductive aging, and major depression on memory circuitry decline in early midlife.Brain research · 2019Article
- Cognitive efficiency in late midlife is linked to lifestyle characteristics and allostatic load.Aging · 2019Article
- Prechemotherapy Levels of Plasma Dehydroepiandrosterone and Its Sulfated Form as Predictors of Cancer-Related Cognitive Impairment in Patients with Breast Cancer Receiving Chemotherapy.Pharmacotherapy · 2019Article
- Hormonal Influences on Cognitive Function.The Malaysian journal of medical sciences : MJMS · 2018Review
- Neurocognitive and physical functioning in the Seveso Women's Health Study.Environmental research · 2018Article
- Endogenous sex hormones and memory performance in middle-aged Greek women with subjective memory complaints.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
introductionWe examined the association between endogenous sex hormones and both objective and subjective measures of cognitive function.
methodsWe followed 3044 women up to 23 years in a prospective cohort study. We measured plasma levels of estrone, estrone sulfate, estradiol, androstenedione, testosterone, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S) in 1989-1990, conducted neuropsychologic testing in 1999-2008, and inquired about subjective cognition in 2012.
resultsOverall, we observed little relation between plasma levels of hormones and either neuropsychologic test performance or subjective cognition. However, after adjustment for age and education, we observed a borderline significant association of higher levels of plasma estrone with higher scores for both overall cognition (P trend = .10) and verbal memory (P trend = .08). DISCUSSION: There were no clear associations of endogenous hormone levels at midlife and cognition in later life, although a suggested finding of higher levels of plasma estrone associated with better cognitive function merits further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.