ArticleHuman brain mapping2016
Abnormal brain activation and connectivity to standardized disorder-related visual scenes in social anxiety disorder.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Abnormal neural activation during negative emotion processing in anxiety disorders: a coordinate-based meta-analysis.CNS spectrums · 2024Pooled it
- Cognitive Neural Mechanism of Social Anxiety Disorder: A Meta-Analysis Based on fMRI Studies.International journal of environmental research and public health · 2021Pooled it
- Why are you looking at me like that? Intolerance of uncertainty and emotional face processing in social anxiety disorder.NeuroImage. Clinical · 2026Article
- Eye-tracking evidence of an association between social anxiety and avoidance of threatening faces in healthy women.Frontiers in psychiatry · 2026Article
- Increased default mode network activation in depression and social anxiety during upward social comparison.Social cognitive and affective neuroscience · 2025Article
- Engagement and Disengagement: From the Basic Science of Emotion Regulation to an Anxiety Spectrum.Psychophysiology · 2025Review
- Resting-state amygdala subregion and precuneus connectivity provide evidence for a dimensional approach to studying social anxiety disorder.Translational psychiatry · 2024Article
- Age-related reduction in anxiety and neural encoding of negative emotional memory.Frontiers in aging neuroscience · 2024Article
- Are Socially Relevant Scenes Abnormally Processed in Complex Trauma-Exposed Children?Journal of child & adolescent trauma · 2023Article
- Pre-COVID brain network topology prospectively predicts social anxiety alterations during the COVID-19 pandemic.Neurobiology of stress · 2023Article
- Large-scale brain functional network abnormalities in social anxiety disorder.Psychological medicine · 2023Article
- Comparative Functional Connectivity of Core Brain Regions between Implicit and Explicit Memory Tasks Underlying Negative Emotion in General Anxiety Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Article
- Racial Discrimination and Resting-State Functional Connectivity of Salience Network Nodes in Trauma-Exposed Black Adults in the United States.JAMA network open · 2022Article
- ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.Human brain mapping · 2022Review
- Intrinsic functional connectivity in families genetically enriched for social anxiety disorder - an endophenotype study.EBioMedicine · 2021Article
- Biopsychosocial Model Social Anxiety and Substance Use Revised.Current psychiatry reports · 2021Review
- Imaging the socially-anxious brain: recent advances and future prospects.F1000Research · 2020Review
- Neural Correlates of Self-referential Processing and Their Clinical Implications in Social Anxiety Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Review
- Article
- Cortical alterations in phobic postural vertigo - a multimodal imaging approach.Annals of clinical and translational neurology · 2018Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our understanding of altered emotional processing in social anxiety disorder (SAD) is hampered by a heterogeneity of findings, which is probably due to the vastly different methods and materials used so far. This is why the present functional magnetic resonance imaging (fMRI) study investigated immediate disorder-related threat processing in 30 SAD patients and 30 healthy controls (HC) with a novel, standardized set of highly ecologically valid, disorder-related complex visual scenes. SAD patients rated disorder-related as compared with neutral scenes as more unpleasant, arousing and anxiety-inducing than HC. On the neural level, disorder-related as compared with neutral scenes evoked differential responses in SAD patients in a widespread emotion processing network including (para-)limbic structures (e.g. amygdala, insula, thalamus, globus pallidus) and cortical regions (e.g. dorsomedial prefrontal cortex (dmPFC), posterior cingulate cortex (PCC), and precuneus). Functional connectivity analysis yielded an altered interplay between PCC/precuneus and paralimbic (insula) as well as cortical regions (dmPFC, precuneus) in SAD patients, which emphasizes a central role for PCC/precuneus in disorder-related scene processing. Hyperconnectivity of globus pallidus with amygdala, anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) additionally underlines the relevance of this region in socially anxious threat processing. Our findings stress the importance of specific disorder-related stimuli for the investigation of altered emotion processing in SAD. Disorder-related threat processing in SAD reveals anomalies at multiple stages of emotion processing which may be linked to increased anxiety and to dysfunctionally elevated levels of self-referential processing reported in previous studies.
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