Evidence map›Paper›PMID 26805802›Full record

ArticleMolecules (Basel, Switzerland)2016

Serum Metabolomic Characterization of Liver Fibrosis in Rats and Anti-Fibrotic Effects of Yin-Chen-Hao-Tang.

Hongyang Zhang, Xiaoning Wang, Ping Hu, Wenjun Zhou, Min Zhang, Jia Liu, Yuerong Wang, Ping Liu, Guoan Luo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  7. The Medicinal Plant PairFrontiers in pharmacology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hongyang ZhangSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. hongyang_zhang@ecust.edu.cn.
Xiaoning WangE-Institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. wxntcm@126.com.
Ping HuSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. huping@ecust.edu.cn.
Wenjun ZhouE-Institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. wjzhou678@163.com.
Min ZhangSchool of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. zhangm@ecust.edu.cn.
Jia LiuE-Institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. fionisly@hotmail.com.
Yuerong WangSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. wangyuerong@ecust.edu.cn.
Ping LiuE-Institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. liuliver@vip.sina.com.
Guoan LuoSchool of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. luoga@mail.tsinghua.edu.cn.
East China University of Science and Technology · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yin-Chen-Hao-Tang (YCHT) is a famous Chinese medicine formula which has long been used in clinical practice for treating various liver diseases, such as liver fibrosis. However, to date, the mechanism for its anti-fibrotic effects remains unclear. In this paper, an ultra-performance liquid chromatography-time-of-flight mass spectrometry (UPLC-TOF-MS)-based metabolomic study was performed to characterize dimethylnitrosamine (DMN)-induced liver fibrosis in rats and evaluate the therapeutic effects of YCHT. Partial least squares-discriminant analysis (PLS-DA) showed that the model group was well separated from the control group, whereas the YCHT-treated group exhibited a tendency to restore to the controls. Seven significantly changed fibrosis-related metabolites, including unsaturated fatty acids and lysophosphatidylcholines (Lyso-PCs), were identified. Moreover, statistical analysis demonstrated that YCHT treatment could reverse the levels of most metabolites close to the normal levels. These results, along with histological and biochemical examinations, indicate that YCHT has anti-fibrotic effects, which may be due to the suppression of oxidative stress and resulting lipid peroxidation involved in hepatic fibrogenesis. This study offers new opportunities to improve our understanding of liver fibrosis and the anti-fibrotic mechanisms of YCHT.

Indexed as

MetabolomeMetabolomicsAnimalsBiomarkersChromatography, High Pressure LiquidDisease Models, AnimalDrugs, Chinese HerbalLiverLiver CirrhosisLiver Function TestsRatsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationBiomarkersDrugs, Chinese Herbalyin-chen-hao-tanganti-fibrotic effectslipid peroxidationliver fibrosisoxidative stresspartial least squares-discriminant analysisserum metabolomicsultra-performance liquid chromatography-time-of-flight mass spectrometryYin-Chen-Hao-Tang

Identifiers

PMID26805802
PMCPMC6273494
OpenAlexW2275379041

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.