Evidence map›Paper›PMID 26805790›Full record

ArticleMolecules (Basel, Switzerland)2016

Biocompatible 3D Matrix with Antimicrobial Properties.

Alberto Ion, Ecaterina Andronescu, Dragoș Rădulescu, Marius Rădulescu, Florin Iordache, Bogdan Ștefan Vasile, Adrian Vasile Surdu, Madalina Georgiana Albu, Horia Maniu, Mariana Carmen Chifiriuc and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Bioactive Potential of 3D-Printed Oleo-Gum-Resin Disks:Bioinorganic chemistry and applications · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alberto IonDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania. alberto_ion@yahoo.com.
Ecaterina AndronescuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania. ecaterina.andronescu@upb.ro.
Dragoș RădulescuDepartment of Orthopedics and Traumatology, Bucharest University Hospital, 169 Splaiul Independentei, 050098 Bucharest, Romania. dragosradulescu1988@yahoo.com.
Marius RădulescuDepartment of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania. radulescu_marius@yahoo.com.
Florin IordacheDepartment of Fetal and Adult Stem Cell Therapy, Institute of Cellular Biology and Pathology of Romanian Academy, 8, B.P. Hasdeu, 050568 Bucharest, Romania. floriniordache84@yahoo.com.
Bogdan Ștefan VasileDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania. bogdan.vasile@upb.ro.
Adrian Vasile SurduDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania. adrian_v_surdu@yahoo.com.
Madalina Georgiana AlbuDepartment of Collagen, Branch of Leather and Footwear Research, National Institute of Research and Development for Textile and Leather, 93 I. Minulescu Street, 031215 Bucharest, Romania. albu_mada@yahoo.com.
Horia ManiuDepartment of Fetal and Adult Stem Cell Therapy, Institute of Cellular Biology and Pathology of Romanian Academy, 8, B.P. Hasdeu, 050568 Bucharest, Romania. horia.maniu@gmail.com.
Mariana Carmen ChifiriucMicrobiology Immunology Department, Faculty of Biology, University of Bucharest, 1-3 Portocalelor Lane, Sector 5, 77206 Bucharest, Romania. carmen_balotescu@yahoo.com.
Alexandru Mihai GrumezescuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania. grumezescu@yahoo.com.
Alina Maria HolbanDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania. alina_m_h@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to develop, characterize and assess the biological activity of a new regenerative 3D matrix with antimicrobial properties, based on collagen (COLL), hydroxyapatite (HAp), β-cyclodextrin (β-CD) and usnic acid (UA). The prepared 3D matrix was characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Microscopy (FT-IRM), Transmission Electron Microscopy (TEM), and X-ray Diffraction (XRD). In vitro qualitative and quantitative analyses performed on cultured diploid cells demonstrated that the 3D matrix is biocompatible, allowing the normal development and growth of MG-63 osteoblast-like cells and exhibited an antimicrobial effect, especially on the Staphylococcus aureus strain, explained by the particular higher inhibitory activity of usnic acid (UA) against Gram positive bacterial strains. Our data strongly recommend the obtained 3D matrix to be used as a successful alternative for the fabrication of three dimensional (3D) anti-infective regeneration matrix for bone tissue engineering.

Indexed as

Anti-Infective AgentsBenzofuransBiocompatible MaterialsCell LineCell SurvivalCollagenDurapatiteHumansMaterials TestingMicrobial Sensitivity TestsMicroscopy, Electron, TransmissionSpectroscopy, Fourier Transform InfraredTissue EngineeringTissue ScaffoldsX-Ray DiffractionAnti-Infective AgentsBenzofuransBiocompatible MaterialsCollagenDurapatiteusnic acidbiocompatiblecollagencyclodextrinsdrug deliveryGram positivehydroxyapatitein vitroS. aureususnic acid

Identifiers

PMID26805790
PMCPMC6273771

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.