ArticleAmerican journal of human genetics2016
Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.
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Article in American journal of human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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46citing papers in PubMed, 2 pooled it
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetic variants associated with platelet count are predictive of human disease and physiological markers.Communications biology · 2021Pooled it
- Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.American journal of human genetics · 2016Pooled it
- Platelet count polygenic scores may modify the effect of aspirin in primary prevention of dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Genome-wide association study and predictors of neonatal blood cell traits in Hispanic newborns.American journal of human genetics · 2026Article
- Admixture mapping identifies complex trait associations with local ancestry in themedRxiv : the preprint server for health sciences · 2025Article
- Association of TNF and TLR2 genes with blood parameter levels in Mexican patients with schizophrenia.BMC psychiatry · 2025Article
- Sparse haplotype-based fine-scale local ancestry inference at scale reveals recent selection on immune responses.Nature communications · 2025Article
- Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review.HGG advances · 2025Review
- Haplotype analysis incorporating ancestral origins identified novel genetic loci associated with chicken body weight using an advanced intercross line.Genetics, selection, evolution : GSE · 2024Article
- Genetic basis of pregnancy-associated decreased platelet counts and gestational thrombocytopenia.Blood · 2024Article
- Genomic Variation Affecting MPV and PLT Count in Association with Development of Ischemic Stroke and Its Subtypes.Molecular neurobiology · 2023Article
- Article
- Fast, accurate local ancestry inference with FLARE.American journal of human genetics · 2023Article
- Article
- Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations.BMC medical genomics · 2022Article
- AFA: Ancestry-specific allele frequency estimation in admixed populations: The Hispanic Community Health Study/Study of Latinos.HGG advances · 2022Article
- Secondary analyses for genome-wide association studies using expression quantitative trait loci.Genetic epidemiology · 2022Article
- Whole genome sequence analysis of platelet traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) initiative.Human molecular genetics · 2022Article
- Article
- The Importance of Alpha-Actinin Proteins in Platelet Formation and Function, and Their Causative Role in Congenital Macrothrombocytopenia.International journal of molecular sciences · 2021Review
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Authors and funding
38 authors.
Ursula M SchickDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Deepti JainDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Chani J HodonskyDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA.
Jean V MorrisonDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
James P DavisDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Lisa BrownDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Tamar SoferDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Matthew P ConomosDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Claudia SchurmannCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Caitlin P McHughDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Sarah C NelsonDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Swarooparani VadlamudiDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Adrienne StilpDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Anna PlantingaDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Leslie BaierPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, NIH, 445 North 5(th) Street, Phoenix, AZ 85004, USA.
Stephanie A BienDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA.
Stephanie M GogartenDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Cecelia A LaurieDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA 90502, USA; Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Yongmei LiuSchool of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
Paul L AuerJoseph J. Zilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee, WI 53201, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA.
Adam SzpiroDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Ken RiceDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Kathleen F KerrDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Robert L HansonPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, NIH, 445 North 5(th) Street, Phoenix, AZ 85004, USA.
George PapanicolaouDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA; Division of Endocrinology, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Ruth J F LoosCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Brian L BrowningDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Sharon R BrowningDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Bruce S WeirDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA.
Timothy A ThorntonDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Alex P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA. Electronic address: apreiner@uw.edu.
Funding
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MFollow-Up Studies of a Genome-Wide Association Analysis in Pima IndiansZIADK075012 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BAIER, LESLIE J · 2009 to 2025
$17.9MStructural Analysis Of Candidate Genes For Type 2 Diabetes and ObesityZIADK069071 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BAIER, LESLIE J · 2009 to 2025
$15.4MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MMolecular Profiling of Diabetes and its ComplicationsZIADK075071 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HANSON, ROBERT · 2012 to 2025
$7.4MStatistical Methods for X-Chromosome Genetic DataP01GM099568 · NIGMS · UNIVERSITY OF WASHINGTON · PI THORNTON, TIMOTHY ALVIN · 2012 to 2016
$7.3MThalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6MIdentification and interpretation of introgressed hominin DNA in modern human genomesR01GM110068 · NIGMS · UNIVERSITY OF WASHINGTON · PI AKEY, JOSHUA MICHAEL · 2014 to 2024
$2.6MLeveraging ancestral diversity to map adiposity loci in HispanicsR01DK101855 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAIMAN, CHRISTOPHER ALAN, LOOS, RUTH JF · 2014 to 2016
$2.1MGENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7MStatistical Methods for Cancer Genetic Association Studies with Hidden PopulationK01CA148958 · NCI · UNIVERSITY OF WASHINGTON · PI THORNTON, TIMOTHY ALVIN · 2010 to 2014
$682kIntramural NIH HHSNCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS N01-HC65233NHLBI NIH HHS N01-HC65234NHLBI NIH HHS N01-HC65235NHLBI NIH HHS N01-HC65236NHLBI NIH HHS N01-HC65237NIDDK NIH HHS 1R01DK101855-01NIDDK NIH HHS DK063491NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK101855NIGMS NIH HHS R01 GM110068NIGMS NIH HHS R01-GM110068
Abstract
Platelets play an essential role in hemostasis and thrombosis. We performed a genome-wide association study of platelet count in 12,491 participants of the Hispanic Community Health Study/Study of Latinos by using a mixed-model method that accounts for admixture and family relationships. We discovered and replicated associations with five genes (ACTN1, ETV7, GABBR1-MOG, MEF2C, and ZBTB9-BAK1). Our strongest association was with Amerindian-specific variant rs117672662 (p value = 1.16 × 10(-28)) in ACTN1, a gene implicated in congenital macrothrombocytopenia. rs117672662 exhibited allelic differences in transcriptional activity and protein binding in hematopoietic cells. Our results underscore the value of diverse populations to extend insights into the allelic architecture of complex traits.
Indexed as
Genetic LociPlatelet CountActininAdolescentAdultAgedAllelesGene FrequencyGenetic Association StudiesGenotypeGenotyping TechniquesHispanic or LatinoHumansMEF2 Transcription FactorsMembrane ProteinsMiddle AgedActininACTN1 protein, humanMEF2C protein, humanMEF2 Transcription FactorsMembrane ProteinsReceptors, GABA-BSRPX protein, human
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