ArticleScientific reports2016
Global selection of Plasmodium falciparum virulence antigen expression by host antibodies.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Plasmodium falciparum malaria parasite var gene expression is modified by host antibodies: longitudinal evidence from controlled infections of Kenyan adults with varying natural exposure.BMC infectious diseases · 2017Trial
- scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance.Nature microbiology · 2025Article
- Escaping the enemy's bullets: an update on how malaria parasites evade host immune response.Parasitology research · 2023Review
- Article
- Determinants of brain swelling in pediatric and adult cerebral malaria.JCI insight · 2021Article
- Antibody Levels to Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLγ11 and DBLδ-1 Predict Reduction in Parasite Density.mSystems · 2021Article
- Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season.Nature medicine · 2020Article
- Identification of a conserved var gene in different Plasmodium falciparum strains.Malaria journal · 2020Article
- Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).PLoS pathogens · 2019Article
- Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression.PLoS pathogens · 2019Article
- Tail Wags the Dog? Functional Gene Classes Driving Genome-Wide GC Content in Plasmodium spp.Genome biology and evolution · 2019Article
- ExploringFrontiers in immunology · 2019Article
- Genetics of Malaria Inflammatory Responses: A Pathogenesis Perspective.Frontiers in immunology · 2019Review
- Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions.Microbiology and molecular biology reviews : MMBR · 2018Review
- Parasite-Related Genetic and Epigenetic Aspects and Host Factors InfluencingFrontiers in cellular and infection microbiology · 2018Review
- Host factors that modify Plasmodium falciparum adhesion to endothelial receptors.Scientific reports · 2017Article
- Host age and expression of genes involved in red blood cell invasion in Plasmodium falciparum field isolates.Scientific reports · 2017Article
- Malaria Epigenetics.Cold Spring Harbor perspectives in medicine · 2017Review
- The Role of Chromatin Structure in Gene Regulation of the Human Malaria Parasite.Trends in parasitology · 2017Review
- Expression of the Plasmodium falciparum Clonally Variant clag3 Genes in Human Infections.The Journal of infectious diseases · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Parasite proteins called PfEMP1 that are inserted on the surface of infected erythrocytes, play a key role in the severe pathology associated with infection by the Plasmodium falciparum malaria parasite. These proteins mediate binding of infected cells to the endothelial lining of blood vessels as a strategy to avoid clearance by the spleen and are major targets of naturally acquired immunity. PfEMP1 is encoded by a large multi-gene family called var. Mutually-exclusive transcriptional switching between var genes allows parasites to escape host antibodies. This study examined in detail the patterns of expression of var in a well-characterized sample of parasites from Kenyan Children. Instead of observing clear inverse relationships between the expression of broad sub-classes of PfEMP1, we found that expression of different PfEMP1 groups vary relatively independently. Parasite adaptation to host antibodies also appears to involve a general reduction in detectable var gene expression. We suggest that parasites switch both between different PfEMP1 variants and between high and low expression states. Such a strategy could provide a means of avoiding immunological detection and promoting survival under high levels of host immunity.
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