ArticleAngewandte Chemie (International ed. in English)2016
Stretch-Induced Drug Delivery from Superhydrophobic Polymer Composites: Use of Crack Propagation Failure Modes for Controlling Release Rates.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Edible Superhydrophobic Coatings with Spatial Openings that Transmit Light and Materials.ACS omega · 2026Article
- Cellulose Based Nano-Scaffolds for Targeted Cancer Therapies: Current Status and Future Perspective.International journal of nanomedicine · 2025Review
- Drug Delivery Opportunities in Esophageal Cancer: Current Treatments and Future Prospects.Molecular pharmaceutics · 2024Review
- Advancements in Skin-Mediated Drug Delivery: Mechanisms, Techniques, and Applications.Advanced healthcare materials · 2024Review
- Challenges and strategies for commercialization and widespread practical applications of superhydrophobic surfaces.Science advances · 2023Review
- Doxorubicin-Loaded Polymeric Meshes Prevent Local Recurrence after Sarcoma Resection While Avoiding Cardiotoxicity.Cancer research · 2022Article
- Design of Reservoirs Enabling Stress-Induced Sequential Release Systems.Pharmaceutics · 2022Article
- Recent advances in mechanical force-responsive drug delivery systems.Nanoscale advances · 2022Review
- Injectable, Anti-Cancer Drug-Eluted Chitosan Microspheres against Osteosarcoma.Journal of functional biomaterials · 2022Article
- Tailoring Materials with Specific Wettability in Biomedical Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Chemically reactive protein nanoparticles for synthesis of a durable and deformable superhydrophobic material.Nanoscale advances · 2019Article
- Piperlongumine-Eluting Gastrointestinal Stent Using Reactive Oxygen Species-Sensitive Nanofiber Mats for Inhibition of Cholangiocarcinoma Cells.Nanoscale research letters · 2019Article
- Smart hydrogels with high tunability of stiffness as a biomimetic cell carrier.Cell biology international · 2019Review
- A bottom-up synthesis of rare-earth-hydrotalcite monolayer nanosheets toward multimode imaging and synergetic therapy.Chemical science · 2018Article
- Tension-Activated Delivery of Small Molecules and Proteins from Superhydrophobic Composites.Advanced healthcare materials · 2018Article
- Bio-Inspired Polymeric Structures with Special Wettability and Their Applications: An Overview.Polymers · 2017Review
- Mechanoresponsive materials for drug delivery: Harnessing forces for controlled release.Advanced drug delivery reviews · 2017Review
- Superhydrophobic materials for biomedical applications.Biomaterials · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The concept of using crack propagation in polymeric materials to control drug release and its first demonstration are reported. The composite drug delivery system consists of highly-textured superhydrophobic electrosprayed microparticle coatings, composed of biodegradable and biocompatible polymers poly(caprolactone) and poly(glycerol monostearate carbonate-co-caprolactone), and a cellulose/polyester core. The release of entrapped agents is controlled by the magnitude of applied strain, resulting in a graded response from water infiltration through the propagating patterned cracks in the coating. Strain-dependent delivery of the anticancer agents cisplatin and 7-ethyl-10-hydroxycamptothecin to esophageal cancer cells (OE33) in vitro is observed. Finally the device is integrated with an esophageal stent to demonstrate delivery of fluorescein diacetate, using applied tension, to an ex vivo esophagus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.