Evidence map›Paper›PMID 26803900›Full record

ArticleGenome medicine2016

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease.

Corey T Watson, Panos Roussos, Paras Garg, Daniel J Ho, Nidha Azam, Pavel L Katsel, Vahram Haroutunian, Andrew J Sharp

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 5 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 5 syntheses or guidelines pooled it, 212 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Review
  8. Review
  9. Long-read sequencing reveals genomic and epigenomic variation in the dark genome of human Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  10. Article
  11. Review
  12. Delineating blood DNA methylation biomarkers for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. DNA Methylation in Alzheimer's Disease.Current topics in behavioral neurosciences · 2025
    Review

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Corey T WatsonDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Panos RoussosDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Paras GargDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniel J HoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nidha AzamDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pavel L KatselDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Vahram HaroutunianDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew J SharpDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. andrew.sharp@mssm.edu.
Icahn School of Medicine at Mount Sinai · US

Funding

VESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI ROBAKIS, NIKOLAOS K · 1985 to 2019
$37.9M
Higher Order Chromatin and Genetic Risk for Alzheimer's DiseaseR01AG050986 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROUSSOS, PANAGIOTIS · 2015 to 2025
$11.2M
Epigenetic Determinants of Major Depression: a Monozygotic Discordant TwinStudyR01MH097018 · NIMH · UNIVERSITY OF FLORIDA · PI SHARP, ANDREW JAMES, STRACHAN, ERIC DANIEL · 2013 to 2017
$3.3M
Comprehensive identification of parent of origin effects in human and mouseR01HG006696 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SHARP, ANDREW JAMES · 2012 to 2016
$2.5M
Multigenerational Epigenetic Effects of Cannabis ExposureR01DA033660 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HURD, YASMIN L. · 2012 to 2016
$2.3M
Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M
Genome-wide analyses of parent of origin effects in three human diseaR03HD073731 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SHARP, ANDREW JAMES · 2013 to 2014
$167k
Dissecting Cis Regulation of Gene Expression in SchizophreniaI01BX002395 · VA · JAMES J PETERS VA MEDICAL CENTER · PI ROUSSOS, PANAGIOTIS · 2014 to 2022
–
BLRD VA I01 BX002395NHGRI NIH HHS HG006696NHGRI NIH HHS R01 HG006696NIA NIH HHS AG05138NIA NIH HHS P50 AG005138NIA NIH HHS R01 AG050986NIA NIH HHS R01AG050986NICHD NIH HHS HD073731NICHD NIH HHS R03 HD073731NIDA NIH HHS DA033660NIDA NIH HHS R01 DA033660NIH HHS S10 OD018522NIMH NIH HHS MH097018NIMH NIH HHS R01 MH097018PHS HHS HHSN271291300031
6 · The paper itself

Abstract

backgroundAlzheimer's disease affects ~13% of people in the United States 65 years and older, making it the most common neurodegenerative disorder. Recent work has identified roles for environmental, genetic, and epigenetic factors in Alzheimer's disease risk.

methodsWe performed a genome-wide screen of DNA methylation using the Illumina Infinium HumanMethylation450 platform on bulk tissue samples from the superior temporal gyrus of patients with Alzheimer's disease and non-demented controls. We paired a sliding window approach with multivariate linear regression to characterize Alzheimer's disease-associated differentially methylated regions (DMRs).

resultsWe identified 479 DMRs exhibiting a strong bias for hypermethylated changes, a subset of which were independently associated with aging. DMR intervals overlapped 475 RefSeq genes enriched for gene ontology categories with relevant roles in neuron function and development, as well as cellular metabolism, and included genes reported in Alzheimer's disease genome-wide and epigenome-wide association studies. DMRs were enriched for brain-specific histone signatures and for binding motifs of transcription factors with roles in the brain and Alzheimer's disease pathology. Notably, hypermethylated DMRs preferentially overlapped poised promoter regions, marked by H3K27me3 and H3K4me3, previously shown to co-localize with aging-associated hypermethylation. Finally, the integration of DMR-associated single nucleotide polymorphisms with Alzheimer's disease genome-wide association study risk loci and brain expression quantitative trait loci highlights multiple potential DMRs of interest for further functional analysis.

conclusionWe have characterized changes in DNA methylation in the superior temporal gyrus of patients with Alzheimer's disease, highlighting novel loci that facilitate better characterization of pathways and mechanisms underlying Alzheimer's disease pathogenesis, and improve our understanding of epigenetic signatures that may contribute to the development of disease.

Indexed as

DNA MethylationGene Regulatory NetworksAgedAged, 80 and overAlzheimer DiseaseEpigenesis, GeneticGene OntologyGenome-Wide Association StudyHumansTemporal Lobe

Identifiers

PMID26803900
PMCPMC4719699
OpenAlexW2279197036

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.