ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2016
Outbreak of NDM-1-producing Klebsiella pneumoniae ST76 and ST37 isolates in neonates.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Pooled it
- Prevalence and clonal diversity of carbapenem-resistant Klebsiella pneumoniae causing neonatal infections: A systematic review of 128 articles across 30 countries.PLoS medicine · 2023Pooled it
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- Emergence of hypervirulent and carbapenem-resistantFrontiers in microbiology · 2026Article
- Antibiotic contamination and antimicrobial resistance dynamics in the urban sewage microbiome in India.Nature communications · 2025Article
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- Emergence and characterization of a novel ST627-KL8 carbapenem-resistantFrontiers in microbiology · 2025Article
- Epidemiology and molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolated from neonatal intensive care units in General Hospital of Ningxia Medical University, China, 2017-2021.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Prevalence of carbapenem-resistant Enterobacterales withJAC-antimicrobial resistance · 2024Article
- Identification of serotype O3b and high-risk clone ST37 ofFrontiers in cellular and infection microbiology · 2024Article
- Global emergence of carbapenem-resistantComputational and structural biotechnology journal · 2023Article
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- Clonal and Horizontal Transmission ofMicrobiology spectrum · 2022Article
- ＜Editors' Choice＞ Multicenter survey for carbapenemase-producing Enterobacterales in central Japan.Nagoya journal of medical science · 2022Article
- Characterization and Public Health Insights of the New Delhi Metallo-β-Lactamase-ProducingMicroorganisms · 2022Article
- Clinical carbapenem-resistantFrontiers in cellular and infection microbiology · 2022Article
- Infective endocarditis caused by Enterobacteriaceae: phenotypic and molecular characterization of Escherichia coli and Klebsiella pneumoniae in Rio de Janeiro, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Thiosemicarbazones exhibit inhibitory efficacy against New Delhi metallo-β-lactamase-1 (NDM-1).The Journal of antibiotics · 2021Article
- Bacterial characteristics of carbapenem-resistant Enterobacteriaceae (CRE) colonized strains and their correlation with subsequent infection.BMC infectious diseases · 2021Article
- Does an Antibiotic Stewardship Applied in a Pig Farm Lead to Low ESBL Prevalence?Antibiotics (Basel, Switzerland) · 2021Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate the epidemiological characteristics of carbapenem-resistant Klebsiella pneumoniae (CRKP) in Shanghai Children's Hospital in China. Twenty-two non-duplicate CRKP strains were collected from pediatric patients between March and June in 2014. Antimicrobial susceptibility testing was conducted by the agar dilution method. Beta-lactamases were characterized by polymerase chain reaction (PCR) and DNA sequencing. The transferability of bla NDM-1 was investigated by conjugation experiment. The plasmids bearing antibiotic resistance genes were characterized by S1 nuclease pulsed-field gel electrophoresis (S1-PFGE) and Southern hybridization. Clonal relatedness was evaluated by PFGE and multilocus sequence typing (MLST). The clinical data of patients were retrospectively reviewed. The 22 CRKP strains were resistant to most of the antimicrobial agents tested, except tigecycline and colistin. Overall, 59, 77, and 100 % of these strains were resistant to imipenem, meropenem, and ertapenem, respectively. The bla NDM-1 was positive in 77.3 % (17/22) of the CRKP strains, of which the 16 isolates from inpatients were designated as ST37 (n = 9) and ST76 (n =7) and one isolate from an outpatient belonged to ST846. The 17 bla NDM-1-positive isolates belonged to PFGE type A (n = 9), type C (n = 7), or type B (n = 1). The plasmids bearing bla NDM-1 could be transferred into recipient Escherichia coli J53 through conjugation in 88.2 % (15/17) of the strains. The hybridization results showed that the plasmids carrying the bla NDM-1 gene were approximately 50-240 kb in size. This is the first report of an outbreak caused by NDM-1-producing K. pneumoniae ST76 and ST37 among neonates.
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