ReviewCurrent opinion in structural biology2016
CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast.
Review in Current opinion in structural biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- METTL16 in cancer: Roles and regulatory mechanisms.Genes & diseases · 2026Review
- Structural basis of circularly permuted group II intron self-splicing.Nature structural & molecular biology · 2025Article
- The spliceosome-associated protein CWC15 promotes miRNA biogenesis in Arabidopsis.Nature communications · 2024Article
- The SMN complex drives structural changes in human snRNAs to enable snRNP assembly.Nature communications · 2023Article
- Phylogenetic Analysis of Spliceosome SF3a2 in Different Plant Species.International journal of molecular sciences · 2023Article
- METTL16, Methyltransferase-Like Protein 16: Current Insights into Structure and Function.International journal of molecular sciences · 2021Review
- Multiple information carried by RNAs: total eclipse or a light at the end of the tunnel?RNA biology · 2020Review
- The integral spliceosomal component CWC15 is required for development in Arabidopsis.Scientific reports · 2020Article
- Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy.Nature communications · 2020Article
- Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control.Wiley interdisciplinary reviews. RNA · 2019Review
- Technique Development for Probing RNA Structure In Vivo and Genome-Wide.Cold Spring Harbor perspectives in biology · 2018Review
- All-atom simulations disentangle the functional dynamics underlying gene maturation in the intron lariat spliceosome.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.Nature medicine · 2018Article
- Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography.Nucleic acids research · 2018Article
- Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications.Molecular cell · 2017Article
- The group II intron maturase: a reverse transcriptase and splicing factor go hand in hand.Current opinion in structural biology · 2017Review
- Mobile Group II Introns as Ancestral Eukaryotic Elements.Trends in genetics : TIG · 2017Review
- Cryo-EM: beyond the microscope.Current opinion in structural biology · 2017Review
- A Challenging Pie to Splice: Drugging the Spliceosome.Angewandte Chemie (International ed. in English) · 2017Review
- Structural Basis for Substrate Helix Remodeling and Cleavage Loop Activation in the Varkud Satellite Ribozyme.Journal of the American Chemical Society · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The spliceosome is formed on pre-mRNA substrates from five small nuclear ribonucleoprotein particles (U1, U2, U4/U6 and U5 snRNPs), and numerous non-snRNP factors. Saccharomyces cerevisiae U4/U6.U5 tri-snRNP comprises U5 snRNA, U4/U6 snRNA duplex and approximately 30 proteins and represents a substantial part of the spliceosome before activation. Schizosaccharomyces pombe U2.U6.U5 spliceosomal complex is a post-catalytic intron lariat spliceosome containing U2 and U5 snRNPs, NTC (nineteen complex), NTC-related proteins (NTR), U6 snRNA, and an RNA intron lariat. Two recent papers describe near-complete atomic structures of these complexes based on cryoEM single-particle analysis. The U4/U6.U5 tri-snRNP structure provides crucial insight into the activation mechanism of the spliceosome. The U2.U6.U5 complex reveals the striking architecture of NTC and NTR and important features of the group II intron-like catalytic RNA core remaining after spliced mRNA is released. These two structures greatly advance our understanding of the mechanism of pre-mRNA splicing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.