ReviewInvestigative ophthalmology & visual science2016
Use and Misuse of Laplace's Law in Ophthalmology.
Review in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Corneal Geometry and Refractive Fluctuations Throughout the Day in Orthokeratology Wearers: A Preliminary Study.Vision (Basel, Switzerland) · 2026Article
- Diurnal Variations in Anterior and Posterior Corneal Thickness and Curvature in Healthy Eyes: Global and Sector-Based Metrics and Lifestyle Associations.Life (Basel, Switzerland) · 2026Article
- Biomechanical changes of tree shrew posterior sclera during experimental myopia, after retrobulbar vehicle injections, and crosslinking using genipin.Scientific reports · 2024Article
- Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell.Experimental eye research · 2023Article
- Delayed reorganisation of F-actin cytoskeleton and reversible chromatin condensation in scleral fibroblasts under simulated pathological strain.Biochemistry and biophysics reports · 2022Article
- Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy.Experimental eye research · 2022Article
- Optical coherence elastography for assessing the influence of intraocular pressure on elastic wave dispersion in the cornea.Journal of the mechanical behavior of biomedical materials · 2022Article
- Lowering Intraocular Pressure: A Potential Approach for Controlling High Myopia Progression.Investigative ophthalmology & visual science · 2021Article
- Collagen V insufficiency in a mouse model for Ehlers Danlos-syndrome affects viscoelastic biomechanical properties explaining thin and brittle corneas.Scientific reports · 2021Article
- Effect of different preconditioning protocols on the viscoelastic inflation response of the posterior sclera.Acta biomaterialia · 2021Article
- Heartbeat-Induced Corneal Axial Displacement and Strain Measured by High Frequency Ultrasound Elastography in Human Volunteers.Translational vision science & technology · 2020Article
- So-Called Lamina Cribrosa Defects May Mitigate IOP-Induced Neural Tissue Insult.Investigative ophthalmology & visual science · 2020Article
- The Shape of Posterior Sclera as a Biometric Signature in Open-angle Glaucoma: An Intereye Comparison Study.Journal of glaucoma · 2020Article
- Connective Tissue Remodeling in Myopia and its Potential Role in Increasing Risk of Glaucoma.Current opinion in biomedical engineering · 2020Article
- Comparison of Lamina Cribrosa Morphology in Eyes with Ocular Hypertension and Normal-Tension Glaucoma.Investigative ophthalmology & visual science · 2020Article
- Peripapillary sclera architecture revisited: A tangential fiber model and its biomechanical implications.Acta biomaterialia · 2018Article
- Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult.Investigative ophthalmology & visual science · 2017Article
- Estimation of the mechanical properties of the eye through the study of its vibrational modes.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeLaplace's Law, with its compactness and simplicity, has long been employed in ophthalmology for describing the mechanics of the corneoscleral shell. We questioned the appropriateness of Laplace's Law for computing wall stress in the eye considering the advances in knowledge of ocular biomechanics.
methodsIn this manuscript we recapitulate the formulation of Laplace's Law, as well as common interpretations and uses in ophthalmology. Using numerical modeling, we study how Laplace's Law cannot account for important characteristics of the eye, such as variations in globe shape and size or tissue thickness, anisotropy, viscoelasticity, or that the eye is a living, dynamic organ.
resultsWe show that accounting for various geometrical and material factors, excluded from Laplace's Law, can alter estimates of corneoscleral wall stress as much as 456% and, therefore, that Laplace's Law is unreliable.
conclusionsWe conclude by illustrating how computational techniques, such as finite element modeling, can account for the factors mentioned above, and are thus more suitable tools to provide quantitative characterization of corneoscleral biomechanics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.