ArticleAmerican journal of epidemiology2016
Association of Cognitive Function With Cause-Specific Mortality in Middle and Older Age: Follow-up of Participants in the English Longitudinal Study of Ageing.
Article in American journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 3 of them syntheses that pooled it.
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Who cites it
75 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies.PloS one · 2022 · on this mapPooled it
- The Effect of Multimodal Non-pharmacological Interventions on Cognitive Function Improvement for People With Dementia: A Systematic Review.Frontiers in public health · 2022Pooled it
- Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies.BMJ (Clinical research ed.) · 2017Pooled it
- Insomnia and inflammatory exposure impair spatial memory and cognitive mapping in older adults: a randomized controlled trial.Brain, behavior, and immunity · 2026Trial
- Effectiveness of A Pilates Training Program on Cognitive and Functional Abilities in Postmenopausal Women.International journal of environmental research and public health · 2020Trial
- Cancer treatment-related cognitive impairment.Neuro-oncology advances · 2026Review
- The association between cognitive function trajectories and all-cause mortality in middle-aged and older Chinese adults with cardiovascular disease: A longitudinal study from CHARLS.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Association between becoming a carer in later life and changes in the trajectory of cognitive function: results from the English longitudinal study of ageing.Age and ageing · 2026Article
- Development and validation of MethylCog, a blood DNA methylation proxy for cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Long-term trajectories of memory, depression, and mobility independence before death: a multi-cohort study.Translational psychiatry · 2026Article
- Article
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- The Association Between the Non-essential Metal Mixture and Handgrip Strength in Chinese Community-Dwelling Older Adults.Biological trace element research · 2025Article
- Does Schooling Improve Cognitive Abilities at Older Ages? Causal Evidence From Nonparametric Bounds.Demography · 2025Article
- Trajectories of Cognitive Change and Their Association with All-Cause Mortality Among Chinese Older Adults: Results from the Chinese Longitudinal Healthy Longevity Survey.Behavioral sciences (Basel, Switzerland) · 2025Article
- Association between healthy lifestyle and cognitive decline, all-cause mortality, and mortality from cardiovascular and cerebrovascular diseases: a 10-year population-based prospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Correlation of cognitive impairment with Mediterranean diet and mortality: a prospective cohort study.Frontiers in aging neuroscience · 2025Article
- Life-course neighbourhood deprivation and brain structure in older adults: the Lothian Birth Cohort 1936.Molecular psychiatry · 2024Article
- Mediating effects of physical activities and cognitive function on the relationship between dietary diversity and all-cause mortality in community-dwelling older adults.Journal of global health · 2024Article
- Development and assessment of analytic methods to improve the measurement of cognition in longitudinal studies of aging through the use of substudies with comprehensive neuropsychological testing.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
15 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
We examined the little-tested associations between general cognitive function in middle and older age and later risk of death from chronic diseases. In the English Longitudinal Study of Ageing (2002-2012), 11,391 study participants who were 50-100 years of age at study induction underwent a battery of cognitive tests and provided a range of collateral data. In an analytical sample of 9,204 people (4,982 women), there were 1,488 deaths during follow-up (mean duration, 9.0 years). When we combined scores from 4 cognition tests that represented 3 acknowledged key domains of cognitive functioning (memory, executive function, and processing speed), cognition was inversely associated with deaths from cancer (per each 1-standard-deviation decrease in general cognitive function score, hazard ratio = 1.21, 95% CI: 1.10, 1.33), cardiovascular disease (hazard ratio = 1.71, 95% CI: 1.55, 1.89), other causes (hazard ratio = 2.07, 95% CI: 1.79, 2.40), and respiratory illness (hazard ratio = 2.48, 95% CI: 2.12, 2.90). Controlling for a range of covariates, such as health behaviors and socioeconomic status, and left-censoring to explore reverse causality had very little impact on the strength of these relationships. These findings indicate that cognitive test scores can provide relatively simple indicators of the risk of death from an array of chronic diseases and that these associations appear to be independent of other commonly assessed risk factors.
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