ReviewCurrent diabetes reports2016
Diabetic Kidney Disease in Adolescents With Type 2 Diabetes: New Insights and Potential Therapies.
Review in Current diabetes reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Proteinuria in adolescence.Pediatric nephrology (Berlin, Germany) · 2026Review
- Undiagnosed pediatric type 2 diabetes mellitus: the giant hidden iceberg.World journal of pediatrics : WJP · 2025Article
- Renal impairment is prevalent in pediatric NAFLD/MASLD and associated with disease severity.Journal of pediatric gastroenterology and nutrition · 2024Article
- Glycoprotein Acetyls Associate With Intraglomerular Hemodynamic Dysfunction, Albuminuria, Central Adiposity, and Insulin Resistance in Youth With Type 1 Diabetes.Canadian journal of diabetes · 2024Article
- A practical evidence-based approach to management of type 2 diabetes in children and young people (CYP): UK consensus.BMC medicine · 2024Article
- Diabetes Complications among Inpatients with Childhood and Young Adult-Onset Type 1 and 2 Diabetes.Pediatric diabetes · 2024Article
- Review
- Glomerular hyperfiltration: part 2-clinical significance in children.Pediatric nephrology (Berlin, Germany) · 2023Review
- Article
- The Aggressive Diabetic Kidney Disease in Youth-Onset Type 2 Diabetes: Pathogenetic Mechanisms and Potential Therapies.Medicina (Kaunas, Lithuania) · 2021Review
- Incorporating Risk Stratification Into the Practice of Pediatric Preventive Cardiology.The Canadian journal of cardiology · 2020Review
- Aspartic acid supplementation ameliorates symptoms of diabetic kidney disease in mice.FEBS open bio · 2020Article
- Five-year kidney outcomes of bariatric surgery differ in severely obese adolescents and adults with and without type 2 diabetes.Kidney international · 2020Article
- The emerging role of dyslipidemia in diabetic microvascular complications.Current opinion in endocrinology, diabetes, and obesity · 2020Review
- The New Biology of Diabetic Kidney Disease-Mechanisms and Therapeutic Implications.Endocrine reviews · 2020Review
- Progress in understanding youth-onset type 2 diabetes in the United States: recent lessons from clinical trials.World journal of pediatrics : WJP · 2019Review
- Metformin monotherapy in children and adolescents with type 2 diabetes mellitus in Japan.Diabetology international · 2019Article
- Clinical and Psychosocial Factors Influencing Retinal Screening Uptake Among Young Adults with Type 2 Diabetes.Current diabetes reports · 2018Review
- Hyperfiltration, urinary albumin excretion, and ambulatory blood pressure in adolescents with Type 1 diabetes mellitus.American journal of physiology. Renal physiology · 2018Observational
- Renal Hyperfiltration in Adolescents with Type 2 Diabetes: Physiology, Sex Differences, and Implications for Diabetic Kidney Disease.Current diabetes reports · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) and dialysis in the Western world. Early DKD, including microalbuminuria and renal hyperfiltration, is common in adolescents with type 2 diabetes (T2D). Furthermore, youth-onset T2D carries a higher risk of progressive DKD than adult-onset T2D of similar diabetes duration. DKD is characterized by a long clinically silent period without signs of disease. Therefore, a major challenge in preventing DKD is the difficulty in identifying high-risk T2D patients at an early stage. The Type 2 Diabetes in Adolescents and Youth (TODAY) study demonstrated a high initial prevalence that increased over time, irrespective of treatment arm. This key observation underscores the importance of discovering new therapeutic targets to supplement conventional management, in order to reduce DKD risk. In this review, we focus on early DKD in T2D and summarize potential novel biomarkers and therapeutic targets.
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