Evidence map›Paper›PMID 26803589›Full record

Trial reportNutrition, metabolism, and cardiovascular diseases : NMCD2016

The effects of a low-carbohydrate diet on appetite: A randomized controlled trial.

T Hu, L Yao, K Reynolds, T Niu, S Li, P Whelton, J He, L Bazzano

Registry-linked trialOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00609271 (Macronutrient Composition of Diet and Risk Factors for Cardiovascular Disease), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00609271 nacompletednot on this map

Macronutrient Composition of Diet and Risk Factors for Cardiovascular Disease

TypeinterventionalSponsorTulane University Health Sciences CenterRan2008 to 2012Enrolled148ConditionsObesity, Body Composition, Blood Pressure, Cardiovascular DiseasesArmslow carbohydrate diet, low fat diet
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

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  18. Dietary Management of Obesity: A Review of the Evidence.Diagnostics (Basel, Switzerland) · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

T HuDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, SL-18, Suite 2000, New Orleans, LA 70112, USA. Electronic address: thu1@tulane.edu.
L YaoDivision of Epidemiology and Community Health, University of Minnesota, 1300 S 2nd St, Suite 300, Minneapolis, MN 55454, USA.
K ReynoldsDepartment of Research & Evaluation, Kaiser Permanente Southern California, 100 South Los Robles, 2nd Floor, Pasadena, CA 91101, USA.
T NiuDepartment of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, SL-18, Suite 2001, New Orleans, LA 70112, USA.
S LiDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, SL-18, Suite 2000, New Orleans, LA 70112, USA.
P WheltonDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, SL-18, Suite 2000, New Orleans, LA 70112, USA.
J HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, SL-18, Suite 2000, New Orleans, LA 70112, USA.
L BazzanoDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, SL-18, Suite 2000, New Orleans, LA 70112, USA.
Tulane University · USKaiser Permanente · USUniversity of Minnesota · US

Funding

TULANE COBRE: TRANSGENIC &GENE-TARGETED ANIMAL COREP20RR017659 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI NAVAR, LUIS GABRIEL · 2002 to 2011
$22.1M
NCRR NIH HHS P20 RR017659
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe relationship between dietary macronutrient composition and appetite is controversial. We examined the effects of a year-long low-carbohydrate diet compared to a low-fat diet on appetite-related hormones and self-reported change in appetite. METHODS AND

resultsA total of 148 adults with a body mass index 30-45 kg/m(2), who were free of diabetes, cardiovascular disease and chronic kidney disease at baseline were randomly assigned to either a low-carbohydrate diet (carbohydrate [excluding dietary fiber]<40 g/day; N = 75) or a low-fat diet (<30% energy from fat, <7% from saturated fat; N = 73). Participants in both groups attended individual and group dietary counseling sessions where they were provided the same behavioral curriculum and advised to maintain baseline levels of physical activity. Appetite and appetite-related hormones were measured at 0, 3, 6 and 12 months of intervention. At 12 months, mean changes (95% CI) in peptide YY were -34.8 pg/mL (-41.0 to -28.6) and in the low-carbohydrate group and -44.2 pg/mL (-50.4 to -38.0) in the low-fat group (net change: 9.54 pg/mL [0.6 to 18.2]; p = 0.036). Approximately 99% of dietary effects on peptide YY are explained by differences in dietary macronutrient content. There was no difference in change in ghrelin or self-reported change in appetite between the groups.

conclusionsA low-fat diet reduced peptide YY more than a low-carbohydrate diet. These findings suggest that satiety may be better preserved on a low-carbohydrate diet, as compared to a low fat diet.

trial registrationclinicaltrials.gov Identifier: NCT00609271.

Indexed as

Appetite RegulationDiet, Carbohydrate-RestrictedDiet, Fat-RestrictedSatiationWeight LossAdultAgedBiomarkersCounselingExerciseFemaleGhrelinHumansMaleMiddle AgedNew OrleansBiomarkersGhrelinGHRL protein, humanPeptide YYAppetiteClinical trialGhrelinLow-carbohydrate dietPeptide YY

Identifiers

PMID26803589
PMCPMC4873405
OpenAlexW2204781019

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.