Evidence map›Paper›PMID 26803489›Full record

Trial reportGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2016

Safety and efficacy of selective retina therapy (SRT) for the treatment of diabetic macular edema in Korean patients.

Young Gun Park, Jae Ryun Kim, Seungbum Kang, Eric Seifert, Dirk Theisen-Kunde, Ralf Brinkmann, Young-Jung Roh

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  6. Review
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  9. Review
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  11. Article
  12. Selective retina therapy (SRT) for macular serous retinal detachment associated with tilted disc syndrome.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  13. Retinal pigment epithelial responses based on the irradiation density of selective retina therapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  14. Article
  15. Selective retina therapy for subretinal fluid associated with choroidal nevus.American journal of ophthalmology case reports · 2020
    Article
  16. Article
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  18. Article
  19. Comparison of the tissue response of selective retina therapy with or without real-time feedback-controlled dosimetry.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
    Article
  20. Comparison of pre-retinal oxygen pressure changes after selective retina therapy versus conventional photocoagulation in the rabbit eye.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Young Gun ParkDepartment of Ophthalmology and Visual Science, Catholic University of Korea, Seoul, Republic of Korea.
Jae Ryun KimDepartment of Ophthalmology and Visual Science, Catholic University of Korea, Seoul, Republic of Korea.
Seungbum KangDepartment of Ophthalmology and Visual Science, Catholic University of Korea, Seoul, Republic of Korea.
Eric SeifertMedical Laser Center Lübeck GmbH, Lübeck, Germany.
Dirk Theisen-KundeMedical Laser Center Lübeck GmbH, Lübeck, Germany.
Ralf BrinkmannMedical Laser Center Lübeck GmbH, Lübeck, Germany.
Young-Jung RohDepartment of Ophthalmology and Visual Science, Catholic University of Korea, Seoul, Republic of Korea. youngjungroh@hanmail.net.
Catholic University of Korea · KRMedizinisches Laserzentrum Lübeck (Germany) · DEYeouido St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSelective retina therapy (SRT) stimulates retinal pigment epithelium (RPE) cell migration and proliferation into irradiated areas. The objective of this study was to evaluate the efficacy and safety of SRT in Korean patients with clinically significant diabetic macular edema (DME).

methodsProspective non-randomized interventional case series study. Twenty-three eyes of 21 patients with clinically significant DME were treated with SRT and followed for 6 months. Patients underwent an evaluation of best corrected visual acuity (BCVA) in Early Treatment Diabetic Retinopathy Study (ETDRS) letters. Microperimetry was employed to measure macular sensitivity within the central 10° field, and the central macular thickness (CMT) and maximum macular thickness (MMT) were measured.

resultsAn improvement in BCVA of one to two ETDRS lines was observed in 41.2 % of patients and an improvement of greater than two lines in 29.4 %. Although there was no significant change in CMT (P > 0.05), MMT decreased from 465.8 ± 87.4 μm to 434.3 ± 83.9 μm (P = 0.006), and mean macular sensitivity increased from 20.8 ± 3.4dB to 22.5 ± 3.5dB (P = 0.02).

conclusionsThe gains in BCVA and improvement in macular sensitivity demonstrated that SRT may be used as an effective and safe treatment modality in Korean patients with clinically significant DME.

Indexed as

AgedDiabetic RetinopathyFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHumansIncidenceLaser TherapyMacular EdemaMaleMiddle AgedOphthalmoscopyProspective StudiesRepublic of KoreaRetinal Pigment EpitheliumDiabetic macular edemaDosimetryMicroperimetryRetinal pigment epitheliumSelective retina therapy

Identifiers

PMID26803489
OpenAlexW2297924305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.