Evidence map›Paper›PMID 26803389›Full record

ArticleUltrasound in medicine & biology2016

Enhancement of Small Molecule Delivery by Pulsed High-Intensity Focused Ultrasound: A Parameter Exploration.

Yufeng Zhou, Yak-Nam Wang, Navid Farr, Jasmine Zia, Hong Chen, Bong Min Ko, Tatiana Khokhlova, Tong Li, Joo Ha Hwang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Dual-Mode 1-D Linear Ultrasound Array for Image-Guided Drug Delivery Enhancement Without Ultrasound Contrast Agents.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023
    Article
  4. Dual-Use Transducer for Ultrasound Imaging and Pulsed Focused Ultrasound Therapy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  5. Inertial Cavitation Behaviors Induced by Nonlinear Focused Ultrasound Pulses.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Yufeng ZhouSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore.
Yak-Nam WangCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington, USA. Electronic address: ynwang@u.washington.edu.
Navid FarrDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Jasmine ZiaDivision of Gastroenterology, School of Medicine, University of Washington, Seattle, Washington, USA.
Hong ChenDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.
Bong Min KoDigestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Asan, Korea.
Tatiana KhokhlovaDivision of Gastroenterology, School of Medicine, University of Washington, Seattle, Washington, USA.
Tong LiDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Joo Ha HwangCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington, USA; Division of Gastroenterology, School of Medicine, University of Washington, Seattle, Washington, USA.
University of Washington · USNanyang Technological University · SGSoonchunhyang University · KRUniversity of Washington Applied Physics Laboratory · USWashington University in St. Louis · US

Funding

Ultrasound enhanced penetration for treatment of pancreatic cancerR01CA154451 · NCI · UNIVERSITY OF WASHINGTON · PI HWANG, JOO HA · 2011 to 2021
$4.3M
High intensity focused ultrasound enhanced drug delivery for local therapy of hepR03DK084126 · NIDDK · UNIVERSITY OF WASHINGTON · PI HWANG, JOO HA · 2009 to 2010
$156k
NCI NIH HHS 1 R01 CA154451NCI NIH HHS R01 CA154451NIDDK NIH HHS 5 R03 DK084126-02NIDDK NIH HHS R03 DK084126
6 · The paper itself

Abstract

Chemotherapeutic drug delivery is often ineffective within solid tumors, but increasing the drug dose would result in systemic toxicity. The use of high-intensity focused ultrasound (HIFU) has the potential to enhance penetration of small molecules. However, operation parameters need to be optimized before the use of chemotherapeutic drugs in vivo and translation to clinical trials. In this study, the effects of pulsed HIFU (pHIFU) parameters (spatial-average pulse-average intensity, duty factor and pulse repetition frequency) on the penetration as well as content of small molecules were evaluated in ex vivo porcine kidneys. Specific HIFU parameters resulted in more than 40 times greater Evans blue content and 3.5 times the penetration depth compared with untreated samples. When selected parameters were applied to porcine kidneys in vivo, a 2.3-fold increase in concentration was obtained after a 2-min exposure to pHIFU. Pulsed HIFU has been found to be an effective modality to enhance both the concentration and penetration depth of small molecules in tissue using the optimized HIFU parameters. Although, performed in normal tissue, this study has the promise of translation into tumor tissue.

Indexed as

AnimalsDiffusionDose-Response Relationship, DrugDrug SynergismEvans BlueHigh-Energy Shock WavesHigh-Intensity Focused Ultrasound AblationIn Vitro TechniquesKidneyRadiation DosageSonicationSwineEvans BlueContent and penetrationDrug deliveryKidneyPulsed-high intensity focused ultrasoundUltrasound parameters

Identifiers

PMID26803389
PMCPMC4775378
OpenAlexW2279448469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.