Evidence map›Paper›PMID 26803316›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2016

Effect of rectal enemas on rectal dosimetric parameters during high-dose-rate vaginal cuff brachytherapy: A prospective trial.

Sebastià Sabater, Ignacio Andrés, Marina Gascon, Angeles Rovirosa, Marimar Sevillano, Roberto Berenguer, Cristina Camacho-Lopez, Manuel Aguayo, Maria Victoria Villas, Meritxell Arenas

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Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sebastià SabaterDepartment of Radiation Oncology, Complejo Hospitalario Universitario de Albacete (CHUA), C/Hnos Falcó 37, 02006, Albacete, Spain. ssabaterm@gmail.com.
Ignacio AndrésDepartment of Radiation Oncology, Complejo Hospitalario Universitario de Albacete (CHUA), C/Hnos Falcó 37, 02006, Albacete, Spain.
Marina GasconDepartment of Radiation Oncology, Hospital Universitari Sant Joan, Reus, Spain.
Angeles RovirosaGynecological Cancer Unit, Radiation Oncology Department, ICMHO, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain.
Marimar SevillanoDepartment of Radiation Oncology, Complejo Hospitalario Universitario de Albacete (CHUA), C/Hnos Falcó 37, 02006, Albacete, Spain.
Roberto BerenguerDepartment of Radiation Oncology, Complejo Hospitalario Universitario de Albacete (CHUA), C/Hnos Falcó 37, 02006, Albacete, Spain.
Cristina Camacho-LopezGynecological Cancer Unit, Radiation Oncology Department, ICMHO, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain.
Manuel AguayoDepartment of Radiation Oncology, Complejo Hospitalario Universitario de Albacete (CHUA), C/Hnos Falcó 37, 02006, Albacete, Spain.
Maria Victoria VillasDepartment of Radiation Oncology, Complejo Hospitalario Universitario de Albacete (CHUA), C/Hnos Falcó 37, 02006, Albacete, Spain.
Meritxell ArenasDepartment of Radiation Oncology, Hospital Universitari Sant Joan, Reus, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effects of rectal enemas on rectal doses during postoperative high-dose-rate (HDR) vaginal cuff brachytherapy (VCB). PATIENTS AND

methodsThis prospective trial included 59 patients. Two rectal cleansing enemas were self-administered before the second fraction, and fraction 1 was considered the basal status. Dose-volume histogram (DVH) values were generated for the rectum and correlated with rectal volume variation. Statistical analyses used paired and unpaired t-tests.

resultsDespite a significant 15 % reduction in mean rectal volume (44.07 vs. 52.15 cc, p = 0.0018), 35.6 % of patients had larger rectums after rectal enemas. No significant rectal enema-related DVH differences were observed compared to the basal data. Although not statistically significant, rectal cleansing-associated increases in mean rectal DVH values were observed: D0.1 cc: 6.6 vs. 7.21 Gy; D1 cc: 5.35 vs. 5.52 Gy; D2 cc: 4.67 vs. 4.72 Gy, before and after rectal cleaning, respectively (where Dx cc is the dose to the most exposed x cm(3)). No differences were observed in DVH parameters according to rectal volume increase or decrease after the enema. Patients whose rectal volume increased also had significantly larger DVH parameters, except for D5 %, D25 %, and D50 %. In contrast, in patients whose rectal volume decreased, significance was only seen for D25 % and D50 % (Dx % dose covering x % of the volume). In the latter patients, nonsignificant reductions in D2 cc, D5 cc and V5 Gy (volume receiving at least 5 Gy) were observed.

conclusionThe current rectal enemas protocol was ineffective in significantly modifying rectal DVH parameters for HDR-VCB.

Indexed as

EnemaRadiotherapy DosageRadiotherapy, High-EnergyAdenocarcinomaAdultAgedBrachytherapyCarcinoma, Squamous CellDose Fractionation, RadiationEndometrial NeoplasmsFemaleHumansImaging, Three-DimensionalIridium RadioisotopesMiddle AgedNeoplasm StagingIridium RadioisotopesDose–volume histogramEndometrial carcinomaRadiotherapyRecommendationsToxicity

Identifiers

PMID26803316

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.