Evidence map›Paper›PMID 26803311›Full record

ArticleJournal of molecular neuroscience : MN2016

Serum Response Factor Protects Retinal Ganglion Cells Against High-Glucose Damage.

Yan Cao, Liang Wang, Junhong Zhao, Hongbing Zhang, Ying Tian, Houcheng Liang, Qiang Ma

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. The MADS-box genesFrontiers in plant science · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yan CaoDepartment of Ophthalmology, Xi'an NO.1 Hospital, No. 30 Fen Alley South Street, Xi'an, 710002, China.
Liang WangDepartment of Ophthalmology, Xi'an NO.1 Hospital, No. 30 Fen Alley South Street, Xi'an, 710002, China.
Junhong ZhaoDepartment of Ophthalmology, Xi'an NO.1 Hospital, No. 30 Fen Alley South Street, Xi'an, 710002, China.
Hongbing ZhangDepartment of Ophthalmology, Xi'an NO.1 Hospital, No. 30 Fen Alley South Street, Xi'an, 710002, China.
Ying TianDepartment of Ophthalmology, Xi'an NO.1 Hospital, No. 30 Fen Alley South Street, Xi'an, 710002, China.
Houcheng LiangDepartment of Ophthalmology, Xi'an NO.1 Hospital, No. 30 Fen Alley South Street, Xi'an, 710002, China.
Qiang MaDepartment of Ophthalmology, Xi'an NO.1 Hospital, No. 30 Fen Alley South Street, Xi'an, 710002, China. qiangmaqm@tom.com.
Wuhan No.1 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum response factor (SRF), which encodes the MADS-box family of related proteins, is a common transcription factor related to the expression of genes associated with cell survival. However, SRF's role in retinal ganglion cells (RGCs) after high-glucose injury remains unclear. In this study, we investigate the protective role of SRF after high-glucose injury and its underlying mechanism. The in vitro RGC model subjected to high glucose was established by employing a 50 mmol/L glucose culture environment. As detected by real-time quantitative PCR and Western blot, SRF was significantly upregulated in RGCs treated with high glucose. Overexpression of SRF significantly promoted survival among RGCs exposed to high glucose and inhibited RGC apoptosis. Knockdown of SRF exerted an inverse effect. Moreover, SRF upregulation enhanced expression of an antioxidant protein, nuclear factor erythroid 2-related factor (Nrf2), via control of the Fos-related antigen 1 (Fra-1). SRF upregulation also affected RGC survival after high-glucose treatment. Our findings showed that overexpression of SRF promoted survival of RGCs after high-glucose injury by regulating Fra-1 and Nrf2.

Indexed as

AnimalsApoptosisCells, CulturedFos-Related Antigen 1GlucoseNF-E2-Related Factor 2Proto-Oncogene Proteins c-fosRatsRats, Sprague-DawleyRetinal Ganglion CellsSerum Response FactorUp-RegulationFos-Related Antigen 1GlucoseNfe2l2 protein, ratNF-E2-Related Factor 2Proto-Oncogene Proteins c-fosSerum Response FactorFra-1High glucoseNrf2OverexpressionSRF

Identifiers

PMID26803311
OpenAlexW2265962354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.