Evidence map›Paper›PMID 26803203›Full record

ArticleBioorganic & medicinal chemistry letters2016

Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase.

Benjamin C Jennings, Amy M Danowitz, Yen-Chih Wang, Richard A Gibbs, Mark D Distefano, Carol A Fierke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Efficient farnesylation of an extended C-terminal C(The Journal of biological chemistry · 2018
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Benjamin C JenningsDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Amy M DanowitzDepartment of Chemistry and Biochemistry, Mercyhurst University, Erie, PA 16546, USA.
Yen-Chih WangDepartment of Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Richard A GibbsDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Mark D DistefanoDepartment of Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Carol A FierkeDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: fierke@umich.edu.
University of Michigan–Ann Arbor · USUniversity of Minnesota · USMercyhurst University · USPurdue University West Lafayette · US

Funding

STRUCTURE/FUNCTION OF ZINC METALLOPROTEINSR01GM040602 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FIERKE, CAROL A · 1993 to 2017
$6.0M
Enzymatic Protein LabelingR01GM084152 · NIGMS · UNIVERSITY OF MINNESOTA · PI DISTEFANO, MARK D · 2010 to 2019
$2.6M
CHEMICAL PROBES OF PROTEIN PRENYLATIONR01CA078819 · NCI · WAYNE STATE UNIVERSITY · PI GIBBS, RICHARD A · 1998 to 2007
$1.1M
Regulation and trafficking of prenylated proteinsF32GM112317 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JENNINGS, BENJAMIN C · 2014 to 2015
$109k
NCI NIH HHS R01 CA078819NCI NIH HHS R01CA078819NIGMS NIH HHS F32 GM112317NIGMS NIH HHS F32GM112317NIGMS NIH HHS R01 GM040602NIGMS NIH HHS R01GM040602NIGMS NIH HHS R01 GM084152NIGMS NIH HHS R01GM084152
6 · The paper itself

Abstract

Attempts to identify the prenyl-proteome of cells or changes in prenylation following drug treatment have used 'clickable' alkyne-modified analogs of the lipid substrates farnesyl- and geranylgeranyl-diphosphate (FPP and GGPP). We characterized the reactivity of four alkyne-containing analogs of FPP with purified protein farnesyltransferase and a small library of dansylated peptides using an in vitro continuous spectrofluorimetric assay. These analogs alter prenylation specificity and reactivity suggesting that in vivo results obtained using these FPP analogs should be interpreted cautiously.

Indexed as

Alkyl and Aryl TransferasesAlkynesClick ChemistryKineticsPeptidesPolyisoprenyl PhosphatesProtein PrenylationSesquiterpenesSubstrate SpecificityAlkyl and Aryl TransferasesAlkynesfarnesyl pyrophosphatep21(ras) farnesyl-protein transferasePeptidesPolyisoprenyl PhosphatesSesquiterpenesClick chemistryPost-translational modificationProtein farnesylationProtein prenylationSubstrate analogs

Identifiers

PMID26803203
PMCPMC4747817
OpenAlexW2199778004

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.