ArticleBrain, behavior, and immunity2016
MHCI promotes developmental synapse elimination and aging-related synapse loss at the vertebrate neuromuscular junction.
Article in Brain, behavior, and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Roles of Microglia in Synaptogenesis, Synaptic Pruning, and Synaptic Plasticity in Physiological Conditions and Central Nervous System Disorders.Current neuropharmacology · 2026Review
- Tremendous Fidelity of Vitamin D3 in Age-related Neurological Disorders.Molecular neurobiology · 2024Review
- Transcriptome and methylome of the supraoptic nucleus provides insights into the age-dependent loss of neuronal plasticity.Frontiers in aging neuroscience · 2023Article
- Crosstalk between short- and long-term calorie restriction transcriptomic signatures with anxiety-like behavior, aging, and neurodegeneration: implications for drug repurposing.Frontiers in behavioral neuroscience · 2023Article
- A Function of Amyloid-β in Mediating Activity-Dependent Axon/Synapse Competition May Unify Its Roles in Brain Physiology and Pathology.Journal of Alzheimer's disease : JAD · 2023Review
- Research Progress on Exosomes and MicroRNAs in the Microenvironment of Postoperative Neurocognitive Disorders.Neurochemical research · 2022Review
- Blockage of neuromuscular glutamate receptors impairs reinnervation following nerve crush in adult mice.Frontiers in cellular neuroscience · 2022Article
- MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling.PLoS biology · 2021Article
- Developmental neuromuscular synapse elimination: Activity-dependence and potential downstream effector mechanisms.Neuroscience letters · 2020Review
- The Neuromuscular Junction in Health and Disease: Molecular Mechanisms Governing Synaptic Formation and Homeostasis.Frontiers in molecular neuroscience · 2020Review
- Tumor necrosis factor alpha mediates neuromuscular synapse elimination.Cell discovery · 2020Article
- Terminal Schwann cell and vacant site mediated synapse elimination at developing neuromuscular junctions.Scientific reports · 2019Article
- Differences in the constituent fiber types contribute to the intermuscular variation in the timing of the developmental synapse elimination.Scientific reports · 2019Article
- Schwann cells participate in synapse elimination at the developing neuromuscular junction.Current opinion in neurobiology · 2017Review
- Article
- Neuromuscular NMDA Receptors Modulate Developmental Synapse Elimination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Major Histocompatibility Complex I Expression by Motor Neurons and Its Implication in Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Synapse elimination at the developing neuromuscular junction (NMJ) sculpts motor circuits, and synapse loss at the aging NMJ drives motor impairments that are a major cause of loss of independence in the elderly. Here we provide evidence that at the NMJ, both developmental synapse elimination and aging-related synapse loss are promoted by specific immune proteins, members of the major histocompatibility complex class I (MHCI). MHCI is expressed at the developing NMJ, and three different methods of reducing MHCI function all disrupt synapse elimination during the second postnatal week, leaving some muscle fibers multiply-innervated, despite otherwise outwardly normal synapse formation and maturation. Conversely, overexpressing MHCI modestly accelerates developmental synapse elimination. MHCI levels at the NMJ rise with aging, and reducing MHCI levels ameliorates muscle denervation in aged mice. These findings identify an unexpected role for MHCI in the elimination of neuromuscular synapses during development, and indicate that reducing MHCI levels can preserve youthful innervation of aging muscle.
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