ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2016
Increased ventricular cerebrospinal fluid lactate in depressed adolescents.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Mitochondrial-inflammation crosstalk in major depressive disorder: molecular mechanisms and therapeutic implications.Molecular psychiatry · 2026Pooled it
- Postmortem evidence of decreased brain pH in major depressive disorder: a systematic review and meta-analysis.Translational psychiatry · 2024Pooled it
- Integrated multi-omics analysis of gut microbiome and serum metabolome in unipolar and bipolar depression.European archives of psychiatry and clinical neuroscience · 2026Article
- Non-severe burn injury leads to sustained molecular changes in the brain in a murine model.Scientific reports · 2026Article
- Increased Cerebrospinal Fluid Lactate Levels in Schizophrenia and Major Depressive Disorder: NCNP Biobank Study in Japan.Neuropsychopharmacology reports · 2026Article
- From energy metabolism to mood regulation: The rise of lactate as a therapeutic target.Journal of advanced research · 2026Review
- Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study.Translational psychiatry · 2025Article
- Childhood insulin resistance and neural stem cell dysfunction in psychiatric disorders: Role ofWorld journal of stem cells · 2025Review
- Resting-State EEG Alterations of Practice-Related Spectral Activity and Connectivity Patterns in Depression.Biomedicines · 2024Article
- Potential for New Therapeutic Approaches by Targeting Lactate and pH Mediated Epigenetic Dysregulation in Major Mental Diseases.Biomedicines · 2024Review
- Mitochondria in depression: The dysfunction of mitochondrial energy metabolism and quality control systems.CNS neuroscience & therapeutics · 2024Review
- Lactate: A Theranostic Biomarker for Metabolic Psychiatry?Antioxidants (Basel, Switzerland) · 2023Review
- Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior.Molecular psychiatry · 2022Article
- The regulatory effects of lactic acid on neuropsychiatric disorders.Discover mental health · 2022Review
- Gut Microbiota Metabolites in Major Depressive Disorder-Deep Insights into Their Pathophysiological Role and Potential Translational Applications.Metabolites · 2022Review
- The maintained attention assessment in patients affected by Myalgic encephalomyelitis/chronic fatigue syndrome: a reliable biomarker?Journal of translational medicine · 2021Article
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Neurological Entity?Medicina (Kaunas, Lithuania) · 2021Review
- L-lactate in cerebrospinal fluid can be used as a biomarker of encephalitis in cattle.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2020Article
- Metabonomic Profile and Signaling Pathway Prediction of Depression-Associated Suicidal Behavior.Frontiers in psychiatry · 2020Article
- Creatine for the Treatment of Depression.Biomolecules · 2019Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMitochondrial dysfunction has been increasingly examined as a potential pathogenic event in psychiatric disorders, although its role early in the course of major depressive disorder (MDD) is unclear. Therefore, the purpose of this study was to investigate mitochondrial dysfunction in medication-free adolescents with MDD through in vivo measurements of neurometabolites using high-spatial resolution multislice/multivoxel proton magnetic resonance spectroscopy.
methodsTwenty-three adolescents with MDD and 29 healthy controls, ages 12-20, were scanned at 3T and concentrations of ventricular cerebrospinal fluid lactate, as well as N-acetyl-aspartate (NAA), total creatine (tCr), and total choline (tCho) in the bilateral caudate, putamen, and thalamus were reported.
resultsAdolescents with MDD exhibited increased ventricular lactate compared to healthy controls [F(1,41)=6.98, P=0.01]. However, there were no group differences in the other neurometabolites. Dimensional analyses in the depressed group showed no relation between any of the neurometabolites and symptomatology, including anhedonia and fatigue.
conclusionsIncreased ventricular lactate in depressed adolescents suggests mitochondrial dysfunction may be present early in the course of MDD; however it is still not known whether the presence of mitochondrial dysfunction is a trait vulnerability of individuals predisposed to psychopathology or a state feature of the disorder. Therefore, there is a need for larger multimodal studies to clarify these chemical findings in the context of network function.
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