ArticleJournal of the American Academy of Child and Adolescent Psychiatry2016
Mode of Anisotropy Reveals Global Diffusion Alterations in Attention-Deficit/Hyperactivity Disorder.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity.Neuroscience and biobehavioral reviews · 2017Pooled it
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- Investigating the causal relationship between multimodal brain imaging-derived phenotypes and insomnia: A Mendelian randomization study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- The integrity of the corticospinal tract and corpus callosum, and the risk of ALS: univariable and multivariable Mendelian randomization.Scientific reports · 2024Article
- Translational In Vivo Assays in Behavioral Biology.Annual review of pharmacology and toxicology · 2024Review
- The cerebellum is causally involved in episodic memory under aging.GeroScience · 2023Article
- Association between attention-deficit/hyperactivity disorder symptom severity and white matter integrity moderated by in-scanner head motion.Translational psychiatry · 2022Article
- The structural connectome in ADHD.Psychoradiology · 2021Review
- Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment following Early Erythropoietin among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection Trial.Brain sciences · 2021Article
- Graph-theoretical analysis of EEG functional connectivity during balance perturbation in traumatic brain injury: A pilot study.Human brain mapping · 2021Article
- Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder.Translational psychiatry · 2021Review
- When attention is intact in adults with ADHD.Psychonomic bulletin & review · 2018Article
- Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders.Journal of clinical neurology (Seoul, Korea) · 2018Review
- Association of White Matter Structure With Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder.JAMA psychiatry · 2017Article
- Imaging genetics in neurodevelopmental psychopathology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- A unique pattern of cortical connectivity characterizes patients with attention deficit disorders: a large electroencephalographic coherence study.BMC medicine · 2017Article
- White Matter Microstructural Alterations in Children with ADHD: Categorical and Dimensional Perspectives.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Disorder-Specific Alteration in White Matter Structural Property in Adults With Autism Spectrum Disorder Relative to Adults With ADHD and Adult Controls.Human brain mapping · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveDiffusion tensor imaging (DTI) can identify structural connectivity alterations in attention-deficit/hyperactivity disorder (ADHD). Most ADHD DTI studies have concentrated on regional differences in fractional anisotropy (FA) despite its limited sensitivity to complex white matter architecture and increasing evidence of global brain differences in ADHD. Here, we examine multiple DTI metrics in separate samples of children and adults with and without ADHD with a principal focus on global between-group differences.
methodTwo samples: adults with ADHD (n = 42) and without (n = 65) and children with ADHD (n = 82) and without (n = 80) were separately group matched for age, sex, and head motion. Five DTI metrics (FA, axial diffusivity, radial diffusivity, mean diffusivity, and mode of anisotropy) were analyzed via tract-based spatial statistics. Group analyses tested for diagnostic differences at the global (averaged across the entire white matter skeleton) and regional level for each metric.
resultsRobust global group differences in diffusion indices were found in adults, with the largest effect size for mode of anisotropy (MA; Cohen's d = 1.45). Global MA also differed significantly between groups in the pediatric sample (d = 0.68). In both samples, global MA increased classification accuracy compared to the model with clinical Conners' ADHD ratings alone. Regional diagnostic differences did not survive familywise correction for multiple comparisons.
conclusionGlobal DTI metrics, particularly the mode of anisotropy, which is sensitive to crossing fibers, capture connectivity abnormalities in ADHD across both pediatric and adult samples. These findings highlight potential diffuse white matter microarchitecture differences in ADHD.
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