ArticleJournal of the American Academy of Child and Adolescent Psychiatry2016
Severity of Cortical Thinning Correlates With Schizophrenia Spectrum Symptoms.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Cognitive Empathy and Longitudinal Changes in Temporo-Parietal Junction Thickness in Schizophrenia.Frontiers in psychiatry · 2021Article
- Associating Psychotic Symptoms with Altered Brain Anatomy in Psychotic Disorders Using Multidimensional Item Response Theory Models.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Cognitive Functioning and Schizotypy: A Four-Years Study.Frontiers in psychiatry · 2020Article
- The continuing story of schizophrenia and schizoaffective disorder: One condition or two?Schizophrenia research. Cognition · 2019Article
- Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveThis study investigated the relationship between regional cortical gray matter thinning and symptoms of schizophrenia spectrum personality disorders (PDs) in siblings of patients with childhood-onset schizophrenia (COS).
methodA total of 66 siblings of patients with COS were assessed for symptoms of schizophrenia spectrum PDs (avoidant, paranoid, schizoid, schizotypal). Structural magnetic resonance images were obtained at approximately 2-year intervals from the siblings and from 62 healthy volunteers matched for age, sex, ethnicity, and handedness. Cortical thickness measures were extracted. Mixed effect regression models were used to test the relationship between symptoms and cortical gray matter thickness in siblings. Cortical thinning was also tested longitudinally in healthy volunteers and siblings.
resultsCortical thinning was found to correlate with symptoms of schizotypal and, to a lesser extent, schizoid PDs. Thinning was most pronounced in the left temporal and parietal lobes and right frontal and parietal regions. Gray matter loss was found to be continuous with that measured in COS. Longitudinal thinning trajectories were found not to differ between siblings and healthy volunteers.
conclusionThe present investigation of cortical thinning in siblings of patients with COS indicates that symptoms of schizophrenia spectrum PDs correlate with regional gray matter loss. This finding supports the idea of cortical thinning as a schizophrenia endophenotype.
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