Evidence map›Paper›PMID 26802570›Full record

ArticleDiabetic medicine : a journal of the British Diabetic Association2017

DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes.

N Bansal, C S Hampe, L Rodriguez, E O'Brian Smith, J Kushner, A Balasubramanyam, M J Redondo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetic medicine : a journal of the British Diabetic Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

N BansalDepartment of Pediatrics, Section of Diabetes and Endocrinology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
C S HampeDepartment of Medicine, University of Washington, Seattle, WA, USA.
L RodriguezDepartment of Pediatrics, Section of Pediatric Endocrinology, Children's Hospital of San Antonio, Baylor College of Medicine, San Antonio, TX, USA.
E O'Brian SmithChildren's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.
J KushnerDepartment of Pediatrics, Section of Diabetes and Endocrinology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
A BalasubramanyamTranslational Metabolism Unit, Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA.
M J RedondoDepartment of Pediatrics, Section of Diabetes and Endocrinology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Baylor College of Medicine · USTexas Children's Hospital · USChildren's Hospital of San Antonio · USChildren's Nutrition Research Center at Baylor College of Medicine · USUniversity of Washington · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
ZOLENDRONIC ACID IN CHILDREN W/ SEVERE OSTEOGENESIS IMPERFECTAM01RR000188 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI SHEARER, WILLIAM THOMAS · 1985 to 2011
$30.6M
ISLET CELL MEMBRANE ANTIBODIES IN DIABTESR01DK026190 · NIDDK · UNIVERSITY OF WASHINGTON · PI HAMPE, CHRISTIANE S · 1986 to 2016
$4.9M
NCRR NIH HHS M01 RR000188NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK026190
6 · The paper itself

Abstract

aimTo study whether DPD epitope-specific glutamate decarboxylase autoantibodies are found more frequently in children with milder forms of Type 1 diabetes.

methodsWe prospectively evaluated 75 children with new-onset autoimmune Type 1 diabetes, in whom we collected demographic, anthropometric and clinical data and measured islet autoantibodies. Glutamate decarboxylase 65 autoantibody-positive samples were analysed for epitope specificities using recombinant Fab against the DPD-defined epitope of glutamate decarboxylase 65.

resultsAfter adjustment for age, positive DPD epitope recognition was significantly associated with higher C-peptide levels at onset (P = 0.02, r

conclusionsOur findings suggest that recognition of the DPD-defined glutamate decarboxylase 65 autoantibody epitope at Type 1 diabetes onset is directly associated with β-cell function, BMI and age, which supports the hypothesis that immunological factors contribute to the clinical heterogeneity of Type 1 diabetes. Larger studies relating epitope-specific glutamate decarboxylase 65 autoantibody to clinical phenotype in children with Type 1 diabetes are warranted.

Indexed as

AdolescentAntibody SpecificityAutoantibodiesCation Transport ProteinsChildChild, PreschoolC-PeptideDiabetes Mellitus, Type 1EpitopesFemaleGlutamate DecarboxylaseHumansInfantMaleReceptor-Like Protein Tyrosine Phosphatases, Class 8Zinc Transporter 8AutoantibodiesCation Transport ProteinsC-PeptideEpitopesGlutamate Decarboxylaseglutamate decarboxylase 2PTPRN2 protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 8SLC30A8 protein, humanZinc Transporter 8

Identifiers

PMID26802570
PMCPMC4958605
OpenAlexW2257059519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.