Evidence map›Paper›PMID 26802367›Full record

ArticleDevelopmental cognitive neuroscience2016

Functional MRI of emotional memory in adolescent depression.

Rosemary J Holt, Julia M Graham, Kirstie J Whitaker, Cindy C Hagan, Cinly Ooi, Paul O Wilkinson, Adrienne O van Nieuwenhuizen, Belinda R Lennox, Barbara J Sahakian, Ian M Goodyer and 2 more

Open access · goldAbstract read
In one paragraph

Article in Developmental cognitive neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Examining memory reconsolidation as a mechanism of nitrous oxide's antidepressant action.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Rosemary J HoltDepartment of Psychiatry, University of Cambridge, UK. Electronic address: rh465@cam.ac.uk.
Julia M GrahamDepartment of Psychiatry, University of Cambridge, UK.
Kirstie J WhitakerDepartment of Psychiatry, University of Cambridge, UK.
Cindy C HaganDepartment of Psychiatry, University of Cambridge, UK.
Cinly OoiDepartment of Psychiatry, University of Cambridge, UK.
Paul O WilkinsonDepartment of Psychiatry, University of Cambridge, UK; Cambridge and Peterborough NHS Foundation Trust, UK.
Adrienne O van NieuwenhuizenCambridge and Peterborough NHS Foundation Trust, UK.
Belinda R LennoxDepartment of Psychiatry, University of Oxford, UK.
Barbara J SahakianDepartment of Psychiatry, University of Cambridge, UK; MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK.
Ian M GoodyerDepartment of Psychiatry, University of Cambridge, UK; Cambridge and Peterborough NHS Foundation Trust, UK; MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK.
Edward T BullmoreDepartment of Psychiatry, University of Cambridge, UK; MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK.
John SucklingDepartment of Psychiatry, University of Cambridge, UK; MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK.
University of Cambridge · GBWellcome Trust · GBCambridgeshire and Peterborough NHS Foundation Trust · GBUniversity of Oxford · GB

Funding

Department of Health 06/05/01Department of Health 97/29/01Medical Research Council G0001354Medical Research Council G0802226Medical Research Council G1000183Wellcome Trust 093875
6 · The paper itself

Abstract

introductionMajor Depressive Disorder (MDD) is a leading cause of disease burden worldwide. Mood-congruent biases in memory tasks are frequently reported in MDD patients, with facilitated memory for negative stimuli. Most functional MRI studies to date have examined the neural correlates of these biases in depressed adults, with fewer studies in adolescents with MDD. Investigation of MDD in adolescence may aid greater understanding of the aetiology and development of the disorder.

methodsCognitive biases were investigated in 56 MDD patients aged 11-17 years and a matched group of 30 healthy control participants with a self-referential memory task. Behavioural performance and BOLD fMRI data were collected during both encoding and retrieval stages.

resultsThe neural response to encoding in adolescents with MDD was found to differ significantly from controls. Additionally, neural responses during encoding and retrieval showed differential relationships with age between patient and control groups, specifically in medial, temporal, and prefrontal regions.

conclusionsThese findings suggest that during adolescence neurophysiological activity associated with emotional memory differs in those with depression compared to controls and may be age sensitive.

Indexed as

AdolescentAdolescent BehaviorAdultAffectBrainChildDepressionEmotionsFemaleHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleMemoryPhotic StimulationAdolescenceDepressionEmotionfMRIMemory

Identifiers

PMID26802367
PMCPMC4913558
OpenAlexW2208935104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.