Evidence map›Paper›PMID 26802259›Full record

ArticleBone2016

Ethnic and geographic variations in the epidemiology of childhood fractures in the United Kingdom.

Rebecca J Moon, Nicholas C Harvey, Elizabeth M Curtis, Frank de Vries, Tjeerd van Staa, Cyrus Cooper

Abstract read
In one paragraph

Article in Bone, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. What are the risk factors and presenting features of premature physeal arrest of the distal radius? A systematic review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2021
    Pooled it
  2. Trial
  3. Article
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  7. Article
  8. Smoking in pregnancy increases offspring fracture risk: yet another reason to encourage smoking cessation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  9. Observational
  10. Improving health-care planning for fracture patients in Türkiye: insights from a nationwide study.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023
    Article
  11. Real-world evidence: new opportunities for osteoporosis research. Recommendations from a Working Group from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Review
  12. Early Life Programming of Skeletal Health.Current osteoporosis reports · 2023
    Review
  13. Paediatric distal radius fractures: an instructional review for the FRCS examination.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023
    Review
  14. Review
  15. Advances in Diagnosis and Management of Childhood OsteoporosisJournal of clinical research in pediatric endocrinology · 2022
    Review
  16. Epidemiology of paediatric lower extremity fractures in a tertiary care center in Switzerland.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Modern management of paediatric tibial shaft fractures: an evidence-based update.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rebecca J MoonMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK; Paediatric Endocrinology, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, SO16 6YD, UK.
Nicholas C HarveyMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK; NIHR Southampton Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK, SO16 6YD, UK.
Elizabeth M CurtisMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK.
Frank de VriesDepartment of Clinical Pharmacy & Toxicology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Tjeerd van StaaHealth eResearch Centre, Farr Institute for Health Informatics Research, University of Manchester, 1.003 Vaughan House, Portsmouth, Road, M13 9PL, UK; Department of Pharmacoepidemiology & Clinical Pharmacology, University of Utrecht, Utrecht, the Netherlands, 3508, TB.
Cyrus CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK; NIHR Southampton Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK, SO16 6YD, UK; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, OX3 7LD, UK. Electronic address: cc@mrc.soton.ac.uk.

Funding

Arthritis Research UK 17702Arthritis Research UK 21231British Heart FoundationDepartment of Health 10/33/04Department of Health HTA/10/33/04Medical Research Council MC_PC_13042Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UU_12011/1Medical Research Council MR/K006665/1Wellcome Trust 201222/Z/16/Z
6 · The paper itself

Abstract

backgroundFractures are common in childhood, and there is considerable variation in the reported incidence across European countries, but few data relating to ethnic and geographic differences within a single country. We therefore aimed to determine the incidence of childhood fractures in the United Kingdom (UK), and to describe age-, ethnicity- and region- specific variations.

methodsThe Clinical Practice Research Datalink (CPRD) contains anonymised electronic health records for approximately 7% of the UK population. The occurrence of a fracture between 1988 and 2012 was determined from the CPRD for all individuals <18years of age, and used to calculate fracture incidence rates for age, sex and ethnicity. Regional fracture incidence rates were also calculated based on general practitioner location within 14 Strategic Health Authorities (SHA) within the UK.

resultsThe overall fracture incidence rate was 137 per 10,000 person-years (py). This was higher in boys (169 per 10,000 py) than girls (103 per 10,000 py) and white children (150 per 10,000 py) compared to those of black (64 per 10,000 py) and South Asian (81 per 10,000 py) ethnicity. Marked geographic variation in incidence was observed. The highest fracture rates were observed in Wales, where boys and girls had 1.82 and 1.97 times greater incidence, respectively, than those residing in Greater London.

conclusionIn the period 1988-2012, there was marked geographic and ethnic variation in childhood fracture incidence across the UK. These findings also implicate lifestyle and socio-economic differences associated with location and ethnicity, and are relevant to policy makers in the UK and internationally.

Indexed as

EthnicityGeographyAge FactorsChildChild, PreschoolFemaleFractures, BoneHumansIncidenceInfantMaleUnited KingdomChildrenCPRDEpidemiologyEthnicityFractureOsteoporosis

Identifiers

PMID26802259
PMCPMC4841386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.