ArticleClinical research in cardiology : official journal of the German Cardiac Society2016
Renal artery sympathetic denervation: observations from the UK experience.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Skin sodium content as a predictor of blood pressure response to renal denervation.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Clinical benefits and safety of renal denervation in severe arterial hypertension: A long-term follow-up study.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Device-based therapies for arterial hypertension.Nature reviews. Cardiology · 2020Review
- New data, new studies, new hopes for renal denervation in patients with uncontrolled hypertension.International Journal of Cardiology. Hypertension · 2019Review
- Joint UK societies' 2019 consensus statement on renal denervation.Heart (British Cardiac Society) · 2019Article
- Renal Denervation: Is It Ready for Prime Time?Current cardiology reports · 2019Review
- Renal Denervation in High-risk Patients with Hypertension.Heart international · 2019Review
- Procedural and anatomical predictors of renal denervation efficacy using two radiofrequency renal denervation catheters in a porcine model.Journal of hypertension · 2018Article
- Hypertension: history and development of established and novel treatments.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Review
- Flow-mediated dilation, nitroglycerin-mediated dilation and their ratio predict successful renal denervation in mild resistant hypertension.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Resistant hypertension: a therapeutic challenge.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Catheter-based renal denervation in hypertension: heading for new shores.Journal of hypertension · 2018Article
- Impact of renal denervation on tissue NaClinical research in cardiology : official journal of the German Cardiac Society · 2018Observational
- Blood pressure response to catheter-based renal sympathetic denervation in severe resistant hypertension: data from the Greek Renal Denervation Registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Interventional procedures and future drug therapy for hypertension.European heart journal · 2017Review
- Renal denervation for treatment of ventricular arrhythmias: data from an International Multicenter Registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Device-based Therapy for Hypertension.Current hypertension reports · 2016Review
- Controversies Surrounding Renal Denervation: Lessons Learned From Real-World Experience in Two United Kingdom Centers.Journal of clinical hypertension (Greenwich, Conn.) · 2016Review
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Authors and funding
36 authors at 20 institutions in 1 country.
Funding
Abstract
backgroundRenal denervation (RDN) may lower blood pressure (BP); however, it is unclear whether medication changes may be confounding results. Furthermore, limited data exist on pattern of ambulatory blood pressure (ABP) response-particularly in those prescribed aldosterone antagonists at the time of RDN.
methodsWe examined all patients treated with RDN for treatment-resistant hypertension in 18 UK centres.
resultsResults from 253 patients treated with five technologies are shown. Pre-procedural mean office BP (OBP) was 185/102 mmHg (SD 26/19; n = 253) and mean daytime ABP was 170/98 mmHg (SD 22/16; n = 186). Median number of antihypertensive drugs was 5.0: 96 % ACEi/ARB; 86 % thiazide/loop diuretic and 55 % aldosterone antagonist. OBP, available in 90 % at 11 months follow-up, was 163/93 mmHg (reduction of 22/9 mmHg). ABP, available in 70 % at 8.5 months follow-up, was 158/91 mmHg (fall of 12/7 mmHg). Mean drug changes post RDN were: 0.36 drugs added, 0.91 withdrawn. Dose changes appeared neutral. Quartile analysis by starting ABP showed mean reductions in systolic ABP after RDN of: 0.4; 6.5; 14.5 and 22.1 mmHg, respectively (p < 0.001 for trend). Use of aldosterone antagonist did not predict response (p > 0.2).
conclusionIn 253 patients treated with RDN, office BP fell by 22/9 mmHg. Ambulatory BP fell by 12/7 mmHg, though little response was seen in the lowermost quartile of starting blood pressure. Fall in BP was not explained by medication changes and aldosterone antagonist use did not affect response.
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