ArticleHuman brain mapping2016
The superficial white matter in Alzheimer's disease.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- A Mechanical Theory for the Formation of Short Association Fibers in the Brain.bioRxiv : the preprint server for biology · 2026Article
- Superficial white matter and gray matter jointly support cognition among older adults in India.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The Association Between Changes in White Matter Microstructure and Cognitive Function in Older Adults with Mild Cognitive Impairment.Brain sciences · 2026Article
- Superficial white matter (SWM) microstructural alterations in Parkinson's disease: a neurite orientation dispersion and density imaging and diffusion tensor imaging study.Quantitative imaging in medicine and surgery · 2026Article
- Superficial white matter microstructural impairments correlate with functional alterations and disease severity in early-stage amyotrophic lateral sclerosis.La Radiologia medica · 2026Article
- Impairment of brain short association fibers across clinical stages in amyotrophic lateral sclerosis: a new biomarker mirroring disease progression.BMC medicine · 2026Article
- Automated characterization of the gray matter white matter distribution demonstrates age-related decline.Scientific reports · 2026Article
- Mapping heterogeneous region- and tissue-specific brain ageing patterns using quantitative MRI.Brain communications · 2026Article
- Impaired capillary-venous drainage contributes to gliosis and demyelination in mouse white matter during aging.Nature neuroscience · 2025Article
- Review
- Keratan Sulfate Is a Multifunctional Brain Glycosaminoglycan With Instructive Capabilities.Journal of neurochemistry · 2025Review
- Association of Superficial White Matter Microstructure With Cortical Pathology Deposition Across Early Stages of the AD Continuum.Neurology · 2025Article
- Microstructural Characterization of Short Association Fibers Related to Long-Range White Matter Tracts in Normative Development.Human brain mapping · 2025Article
- Quantifying axonal features of human superficial white matter from three-dimensional multibeam serial electron microscopy data assisted by deep learning.NeuroImage · 2025Article
- Characterizing the microstructural transition at the gray matter-white matter interface: Implementation and demonstration of age-associated differences.NeuroImage · 2025Article
- Article
- Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study.The journal of headache and pain · 2024Article
- Assessment of the Depiction of Superficial White Matter Using Ultra-High-Resolution Diffusion MRI.Human brain mapping · 2024Article
- Article
- Axonal injury, sleep disturbances, and memory following traumatic brain injury.Annals of clinical and translational neurology · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
White matter abnormalities have been shown in the large deep fibers of Alzheimer's disease patients. However, the late myelinating superficial white matter comprised of intracortical myelin and short-range association fibers has not received much attention. To investigate this area, we extracted a surface corresponding to the superficial white matter beneath the cortex and then applied a cortical pattern-matching approach which allowed us to register and subsequently sample diffusivity along thousands of points at the interface between the gray matter and white matter in 44 patients with Alzheimer's disease (Age: 71.02 ± 5.84, 16M/28F) and 47 healthy controls (Age 69.23 ± 4.45, 19M/28F). In patients we found an overall increase in the axial and radial diffusivity across most of the superficial white matter (P < 0.001) with increases in diffusivity of more than 20% in the bilateral parahippocampal regions and the temporal and frontal lobes. Furthermore, diffusivity correlated with the cognitive deficits measured by the Mini-Mental State Examination scores (P < 0.001). The superficial white matter has a unique microstructure and is critical for the integration of multimodal information during brain maturation and aging. Here we show that there are major abnormalities in patients and the deterioration of these fibers relates to clinical symptoms in Alzheimer's disease.
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