Evidence map›Paper›PMID 26801950›Full record

ArticleTrends in cognitive sciences2016

Drinking During Pregnancy and the Developing Brain: Is Any Amount Safe?

Michael E Charness, Edward P Riley, Elizabeth R Sowell

Abstract read
In one paragraph

Article in Trends in cognitive sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
12.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 78 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Defects of Cortical Microcircuits Following Early Exposure to Alcohol.Advances in experimental medicine and biology · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Fetal alcohol spectrum disorders.Nature reviews. Disease primers · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Michael E CharnessVA Boston Healthcare System and Department of Neurology, Harvard Medical School, Department of Neurology, Boston University School of Medicine, 1400 VFW Parkway, West Roxbury, MA 02132, USA. Electronic address: mcharness@hms.harvard.edu.
Edward P RileyCenter for Behavioral Teratology, San Diego State University, 6330 Alvarado Court, San Diego, CA 92120, USA.
Elizabeth R SowellDevelopmental Cognitive Neuroimaging Laboratory and Department of Pediatrics, Keck School of Medicine, University of Southern California, Institute for the Developing Mind, Children's Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA. Electronic address: esowell@chla.usc.edu.
Boston University · USSan Diego State University · USUniversity of Southern California · US

Funding

Cross-Cultural Assessment of FASDU24AA014811 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY · 2003 to 2026
$13.1M
Mapping the Brain, the Face, and Neurocognitive Function in FASD (U01)U01AA017122 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOWELL, ELIZABETH R · 2007 to 2016
$5.9M
ALCOHOL AND CELL ADHESIONR37AA012974 · NIAAA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CHARNESS, MICHAEL EDWARD · 2002 to 2010
$4.3M
ALCOHOL AND CELL ADHESIONR01AA012974 · NIAAA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CHARNESS, MICHAEL EDWARD · 2001 to 2016
$2.4M
Alcohol AntagonistsI01BX002374 · VA · VA BOSTON HEALTH CARE SYSTEM · PI CHARNESS, MICHAEL EDWARD · 2015 to 2019
–
BLRD VA I01 BX002374NIAAA NIH HHS AA014811NIAAA NIH HHS AA017122NIAAA NIH HHS AA12974NIAAA NIH HHS R01 AA012974NIAAA NIH HHS U24 AA014811
6 · The paper itself

Abstract

Heavy prenatal alcohol exposure can have lifelong, disabling effects on brain and cognition. Unlike animal studies, research on light-to-moderate drinking in humans demonstrates less consistent impact. Discussions of negative research findings in popular media underestimate potential adverse outcomes and complicate decisions about risks versus benefits of light-to-moderate drinking during pregnancy.

Indexed as

Prenatal Exposure Delayed EffectsAlcohol DrinkingBrainFemaleFetal Alcohol Spectrum DisordersGenetic Predisposition to DiseaseHumansPregnancyRiskSocial Stigma

Identifiers

PMID26801950
PMCPMC4788102
OpenAlexW2251893794

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.