Evidence map›Paper›PMID 26801673›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

Biological characteristics of a novel giant cell tumor cell line derived from spine.

Zhenhua Zhou, Yan Li, Leqin Xu, Xudong Wang, Su Chen, Cheng Yang, Jianru Xiao

Abstract read
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In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. ALCAMCell death & disease · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhenhua ZhouDepartment of Bone Tumor Surgery, Changzheng Hospital, The Second Military Medical University, No.415, Fengyang Road, Shanghai, 200433, China.
Yan LiDepartment of Oncology, Shanghai Medical College, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Leqin XuDepartment of Bone Tumor Surgery, Changzheng Hospital, The Second Military Medical University, No.415, Fengyang Road, Shanghai, 200433, China.
Xudong WangDepartment of Bone Tumor Surgery, Changzheng Hospital, The Second Military Medical University, No.415, Fengyang Road, Shanghai, 200433, China.
Su ChenDepartment of Bone Tumor Surgery, Changzheng Hospital, The Second Military Medical University, No.415, Fengyang Road, Shanghai, 200433, China.
Cheng YangDepartment of Bone Tumor Surgery, Changzheng Hospital, The Second Military Medical University, No.415, Fengyang Road, Shanghai, 200433, China.
Jianru XiaoDepartment of Bone Tumor Surgery, Changzheng Hospital, The Second Military Medical University, No.415, Fengyang Road, Shanghai, 200433, China. jianruxiao63@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Giant cell tumor of bone(GCTB) is a special bone tumor for it consists of various cell types, and its biological characteristics is different from common benign or malignant neoplasm. In the present study, we report the biological features of a primary Asian GCTB cell line named GCTB28. We analyzed extensive properties of the GCTB28 cells including morphological observations, growth, cell cycle, karyotype, proliferation, proteins expression, surface biomarker verification, and tumorigenicity in nude mice. We found that the stromal cells of GCTB were endowed with self-renewal capacity and played dominant roles in GCTB development. Moreover, we confirmed that GCTB cells can be CD33(-)CD14(-) phenotype which was not in accord with previous study. This study provides an in vitro model system to investigate pathogenic mechanisms and molecular characteristics of GCTB and also provides a useful tool for researching the therapeutic targeting of GCTB.

Indexed as

AdultAnimalsBiomarkers, TumorBone NeoplasmsCarcinogenesisCell CycleCell Line, TumorCell ProliferationGiant Cell Tumor of BoneHumansLipopolysaccharide ReceptorsMaleMiceMice, NudeSialic Acid Binding Ig-like Lectin 3SpineBiomarkers, TumorLipopolysaccharide ReceptorsSialic Acid Binding Ig-like Lectin 3BiomarkerGiant cell tumor of bone (GCTB)Mononuclear stromal cellsMultinuclear giant cellsNovel cell line of GCTB

Identifiers

PMID26801673

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.