ArticleSocial neuroscience2017
Depressive-like behavior, its sensitization, social buffering, and altered cytokine responses in rhesus macaques moved from outdoor social groups to indoor housing.
Article in Social neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Low circulating adropin concentrations identify vulnerability in learning-dependent cognitive performance in aged rhesus macaques.npj aging · 2026Article
- Paired versus Single Housing of Ferrets (Mustela putorius furo) Does Not Influence Experimental Outcomes of Influenza A Virus Pathogenesis Studies.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Cortisol and Catecholamine Concentrations Are Affected by Repeated Relocations of Adult Female Rhesus Monkeys (Macaca mulatta).American journal of primatology · 2025Article
- Recognising depression in non-human primates: a narrative review of reported signs of depression.PeerJ · 2025Review
- An exploration of the postural, location- and social contact- related sub-characteristics of inactive but awake behaviour as a depression-like indicator in mice.Applied animal behaviour science · 2024Article
- Increased Striatal Presynaptic Dopamine in a Nonhuman Primate Model of Maternal Immune Activation: A Longitudinal Neurodevelopmental Positron Emission Tomography Study With Implications for Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Effects of pair housing on behavior, cortisol, and clinical outcomes during quarantine-like procedures for rhesus macaques (Macaca mulatta).Journal of medical primatology · 2023Article
- The modulatory effects of alkaloid extracts of Cannabis sativa, Datura stramonium, Nicotiana tabacum and male Carica papaya on neurotransmitter, neurotrophic and neuroinflammatory systems linked to anxiety and depression.Inflammopharmacology · 2022Article
- Waking inactivity as a welfare indicator in laboratory mice: investigating postures, facial expressions and depression-like states.Royal Society open science · 2022Article
- Impact of Maternal Immune Activation on Nonhuman Primate Prefrontal Cortex Development: Insights for Schizophrenia.Biological psychiatry · 2022Review
- Challenges with Assessing and Treating Pain in Research Primates: A Focused Survey and Literature Review.Animals : an open access journal from MDPI · 2022Review
- Social housing status impacts rhesus monkeys' affective responding in classic threat processing tasks.Scientific reports · 2022Article
- Monkey's Social Roles Predict Their Affective Reactivity.Affective science · 2021Article
- Evaluation of an enrichment programme for a colony of long-tailed macaques (Macaca fascicularis) in a rescue centre.Primates; journal of primatology · 2021Article
- Recommendations for Abnormal Behaviour Ethograms in Monkey Research.Animals : an open access journal from MDPI · 2021Article
- Prenatal Relocation Stress Enhances Resilience Under Challenge in Infant Rhesus Macaques.Frontiers in behavioral neuroscience · 2021Article
- Animal models of human mood.Neuroscience and biobehavioral reviews · 2021Review
- Effects of Social Housing Changes on Immunity and Vaccine-Specific Immune Responses in Adolescent Male Rhesus Macaques.Frontiers in immunology · 2020Article
- Behavioral predictors of pairing success in rhesus macaques (Macaca mulatta).American journal of primatology · 2020Article
- Increased produce enrichment reduces trauma in socially-housed captive rhesus macaques (Macaca mulatta).American journal of primatology · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Psychosocial stressors appear to promote the onset of depressive illness through activation and sensitization of inflammatory mechanisms. Here, adult male rhesus monkeys brought from large outdoor social groups to indoor housing for 8 days reliably exhibited a hunched, depressive-like posture. When rehoused indoors a second 8 days about 2 weeks later, monkeys housed alone, but not those with an affiliative partner, showed sensitization of the depressive-like hunched posture. Housing indoors also affected circulating pro-inflammatory cytokines: IL-1β showed increased responsiveness to immune challenge, and IL-1β and TNF-α showed reduced suppression by dexamethasone. Sensitivity of the anti-inflammatory cytokine IL-10 to immune challenge exhibited a relative increase from the first to the second round of indoor housing in animals housed in pairs, and a relative decrease in animals housed alone. Cytokine levels during indoor housing were positively correlated with duration of depressive-like behavior. Plasma cortisol levels increased but did not differentiate housing conditions or rounds. Results demonstrate a rapid induction and sensitization of depressive-like behavior to indoor individual housing, social buffering of sensitization, and associated inflammatory responses. This paradigm may provide a practical nonhuman primate model for examining inflammatory-mediated consequences of psychosocial stressors on depression and possible social buffering of these effects.
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Registered trials
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