Evidence map›Paper›PMID 26801477›Full record

ArticleJournal of cardiovascular translational research2016

Pre-clinical Experience with a Multi-Chordal Patch for Mitral Valve Repair.

Surendra K Chawla, Weiwei Shi, Bryant V McIver, Jakob Vinten-Johansen, Robert W M Frater, Muralidhar Padala

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Surendra K ChawlaDivision of Cardiothoracic Surgery, Saint Francis Hospital and Medical Center, Hartford, CT, USA.
Weiwei ShiStructural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Division of Cardiothoracic Surgery, Emory University, 380-B, Northyards Blvd, Atlanta, GA, 30313, USA.
Bryant V McIverStructural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Division of Cardiothoracic Surgery, Emory University, 380-B, Northyards Blvd, Atlanta, GA, 30313, USA.
Jakob Vinten-JohansenStructural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Division of Cardiothoracic Surgery, Emory University, 380-B, Northyards Blvd, Atlanta, GA, 30313, USA.
Robert W M FraterDivision of Cardiothoracic Surgery, Albert Einstein School of Medicine, New York, NY, USA.
Muralidhar PadalaStructural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Division of Cardiothoracic Surgery, Emory University, 380-B, Northyards Blvd, Atlanta, GA, 30313, USA. spadala@emory.edu.
Emory University Hospital Midtown · USAlbert Einstein College of Medicine · USSaint Francis University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surgical repair of flail mitral valve leaflets with neochordoplasty has good outcomes, but implementing it in anterior and bi-leaflet leaflet repair is challenging. Placing and sizing individual neochordae is time consuming and error prone, with persistent localized flail if performed incorrectly. In this study, we report our pre-clinical experience with a novel multi-chordal patch for mitral valve repair. The device was designed based on human cadaver hearts, and laser cut from expanded polytetrafluoroethylene. The prototypes were tested in: (stage 1) ex vivo hearts with leaflet flail (N = 6), (stage 2) acute swine induced with flail (N = 6), and (stage 3) two chronic swine survived to 23 and 120 days (N = 2). A2 and P2 prolapse were successfully repaired with coaptation length restored to 8.1 ± 2.2mm after posterior repair and to 10.2 ± 1.3mm after anterior repair in ex vivo hearts. In vivo, trace regurgitation was seen after repair with excellent patch durability, healing, and endothelialization at euthanasia. A new device for easier mitral repair is reported, with good early pre-clinical outcomes.

Indexed as

Heart Valve ProsthesisAnimalsCadaverChordae TendineaeDisease Models, AnimalEchocardiography, Doppler, ColorHeart Valve Prosthesis ImplantationHumansMitral ValveMitral Valve InsufficiencyMitral Valve ProlapsePolytetrafluoroethyleneProsthesis DesignRecovery of FunctionSus scrofaTime FactorsPolytetrafluoroethyleneChordal replacementDeviceMitral regurgitationMitral valve prolapseMitral valve repairNeochordoplastyRobotic mitral repairValve surgery

Identifiers

PMID26801477
OpenAlexW2270225176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.