Evidence map›Paper›PMID 26801465›Full record

ArticleBMJ open2016

Incidence of multiple myeloma in Great Britain, Sweden, and Malmö, Sweden: the impact of differences in case ascertainment on observed incidence trends.

Ramón Vélez, Ingemar Turesson, Ola Landgren, Sigurdur Y Kristinsson, Jack Cuzick

Abstract read
In one paragraph

Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
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  5. Update on cancer incidence trends in Canada, 1984 to 2017.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2022
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  6. Article
  7. Article
  8. Article
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  10. Article
  11. At-a-glance - Cancer trends in Canada, 1984 to 2015.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2019
    Article
  12. Methods for reducing delays in the diagnosis of multiple myeloma.International journal of hematologic oncology · 2019
    Article
  13. Article
  14. Approach to the Older Adult With Multiple Myeloma.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2019
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ramón VélezDepartment of Medicine, Section on General Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Ingemar TuressonDepartment of Hematology, Skåne University Hospital, Malmö, Sweden.
Ola LandgrenMemorial Sloan-Kettering Cancer Center, New York, New York, USA.
Sigurdur Y KristinssonDepartment of Hematology, University of Iceland, Reykjavik, Iceland.
Jack CuzickCentre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.

Funding

Cancer Research UK 16891
6 · The paper itself

Abstract

objectivesThe increased incidence of multiple myeloma (MM) across China and East Asia stimulated us to examine the current rates in Great Britain, where rates increased dramatically in the second half of the 20th century. However, rates have been stable and high during this period in Malmö, Sweden, where there is a keen interest in MM. We thus assessed recent changes in MM incidence in Great Britain, Sweden overall, and Malmö, Sweden, and examined how these changes might explain recent reports of increased MM incidence across Asia.

designEstimation of MM incidence for Great Britain, Sweden overall, and Malmö, Sweden. POPULATIONS: MM incidence data for Great Britain (1975-2009) were obtained from Cancer Research UK and for Sweden (1970-2009) from the Swedish Cancer Registry. MM incidence data from Malmö, Sweden, were available from 1950 to 2012.

main outcome measuresAge-specific incidence of MM in Great Britain, Sweden overall, and Malmö, Sweden.

resultsMM incidence in Great Britain, Sweden overall, and Malmö increased progressively with age, even among the oldest group. The MM age-adjusted incidence (European standard population) increased by 69% from 1975-1979 to 2005-2009 in Great Britain, from 3.2/100,000 to 5.4/100,000. The largest increases occurred among those 70-79 years of age, for whom rates increased from 17.9/100,000 to 33.6/100,000; reflecting an increase of 69%. During this same period, the age-adjusted incidence (European stand population) in Sweden overall remained stable, at approximately 4.7/100,000.

conclusionsMM age-specific incidence is now similar in Great Britain, Sweden overall, and Malmö. We believe this is a result of improvements in case ascertainment in Great Britain, particularly among the elderly. Similar changes can be predicted to occur across Asia as improved access to healthcare contributes to better diagnosis of MM.

Indexed as

AdultAgedAge DistributionCitiesHumansIncidenceMiddle AgedMultiple MyelomaSwedenUnited KingdomEPIDEMIOLOGY

Identifiers

PMID26801465
PMCPMC4735168

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.