Observational studyEuropean radiology2016
Inter-observer and inter-examination variability of manual vertebral bone attenuation measurements on computed tomography.
Observational study in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed.
- Future Osteoporotic Fracture Risk Related to Lumbar Vertebral Trabecular Attenuation Measured at Routine Body CT.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Trial
- Opportunistic lumbar vertebral CT attenuation is associated with intertrochanteric femur fracture occurrence and fracture instability in older adults.Skeletal radiology · 2026Article
- Disc collapse aggravates vertebral recollapse following percutaneous kyphoplasty: a clinical review and biomechanical study.Quantitative imaging in medicine and surgery · 2026Article
- Disc degeneration did not lead to an increased incidence of adjacent vertebral fractures in wedge-type OVCF patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Degenerative scoliosis may trigger higher incidence of adjacent vertebral fractures following percutaneous vertebroplasty: a clinical evidence-based biomechanical research.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- The Association between Remnant Cholesterol Levels and Computed Tomography-based Low Bone Mass, Low Muscle Mass, and Osteosarcopenia in Older AdultsCurrent medical imaging · 2026Article
- Wider screw spread can reduce the risk of short-term femoral head necrosis by optimizing the fixation stability in femoral neck fracture patients with triangle cannulated screw fixation.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Sagittal-oriented articular processes and intervertebral disc degeneration phenotypes can concurrently lead to an increased presence of annulus tears in the cranial adjacent motion segment : a clinical review and biomechanical simulation.Bone & joint research · 2025Article
- Larger nail-shaft gap as a potential risk factor of femoral head varus in patients treated with proximal femoral nail antirotation fixation: a retrospective, observational, single-center study with corresponding numerical simulation.Quantitative imaging in medicine and surgery · 2025Article
- Predictive value of Hounsfield units and vertebral bone quality on cage subsidence in oblique lateral interbody fusion with bilateral posterior fixation.Journal of orthopaedic surgery and research · 2025Article
- Article
- Factors and Experiences Associated With Unscheduled Hospital Readmission After Lateral Lumbar Interbody Fusion: A Case-Controlled Study.Orthopaedic surgery · 2025Article
- Vertebral CT Hounsfield units in postmenopausal women with osteoporotic vertebral compression fracture: identification and validation of reference intervals.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Assessment of trabecular bone Hounsfield units in the lumbar spine for osteoporosis evaluation in individuals aged 65 and above: a review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- A novel T2-weighted series-based modified vertebral bone quality score for evaluating bone mineral density.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- The association between HDL-c levels and computed tomography-based osteosarcopenia in older adults.BMC musculoskeletal disorders · 2024Article
- The influence of proliferative tissue on Hounsfield unit and its correlation with BMD in middle-aged and elderly patients with lumbar degenerative diseases.Journal of orthopaedic surgery and research · 2024Article
- Exploring bone density analysis on routine CT scans as a tool for opportunistic osteoporosis screening.Scientific reports · 2024Article
- Bone Mineral Density and Clinical Outcome after Ankle Fracture.Journal of bone metabolism · 2024Article
- Gender-Specific Risk Factors for Asymmetric Bone Density in Adult Degenerative Lumbar Scoliosis: A Retrospective Cohort Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine inter-observer and inter-examination variability of manual attenuation measurements of the vertebrae in low-dose unenhanced chest computed tomography (CT).
methodsThree hundred and sixty-seven lung cancer screening trial participants who underwent baseline and repeat unenhanced low-dose CT after 3 months because of an indeterminate lung nodule were included. The CT attenuation value of the first lumbar vertebrae (L1) was measured in all CTs by one observer to obtain inter-examination reliability. Six observers performed measurements in 100 randomly selected CTs to determine agreement with limits of agreement and Bland-Altman plots and reliability with intraclass correlation coefficients (ICCs). Reclassification analyses were performed using a threshold of 110 HU to define osteoporosis.
resultsInter-examination reliability was excellent with an ICC of 0.92 (p < 0.001). Inter-examination limits of agreement ranged from -26 to 28 HU with a mean difference of 1 ± 14 HU. Inter-observer reliability ICCs ranged from 0.70 to 0.91. Inter-examination variability led to 11.2 % reclassification of participants and inter-observer variability led to 22.1 % reclassification.
conclusionsVertebral attenuation values can be manually quantified with good to excellent inter-examination and inter-observer reliability on unenhanced low-dose chest CT. This information is valuable for early detection of osteoporosis on low-dose chest CT. KEY POINTS: • Vertebral attenuation values can be manually quantified on low-dose unenhanced CT reliably. • Vertebral attenuation measurements may be helpful in detecting subclinical low bone density. • This could become of importance in the detection of osteoporosis.
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