Evidence map›Paper›PMID 26801055›Full record

ArticleCirculation2016

Role of Coronary Artery Calcium Score of Zero and Other Negative Risk Markers for Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis (MESA).

Michael J Blaha, Miguel Cainzos-Achirica, Philip Greenland, John W McEvoy, Ron Blankstein, Matthew J Budoff, Zeina Dardari, Christopher T Sibley, Gregory L Burke, Richard A Kronmal and 3 more

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In one paragraph

Article in Circulation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
235citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

235 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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175 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Michael J BlahaFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.). mblaha1@jhmi.edu.
Miguel Cainzos-AchiricaFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.).
Philip GreenlandFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.).
John W McEvoyFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.).
Ron BlanksteinFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.).
Matthew J BudoffFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.).
Zeina DardariFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.).
Christopher T SibleyFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.).
Gregory L BurkeFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.).
Richard A KronmalFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.).
Moyses SzkloFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.).
Roger S BlumenthalFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.).
Khurram NasirFrom Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, MD (M.J.B., M.C.-A., J.W.M., Z.D., R.S.B., K.N.); Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD (M.C.-A.); Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.G.); Brigham and Women's Hospital, Boston, MA (R.B.); Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA (M.J.B.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (C.T.S.); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (G.L.B.); University of Washington, Seattle (R.A.K.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.J.B., M.S.); Center for Healthcare Advancement and Outcomes, and Miami Cardiac and Vascular Institute, Baptist Heath South Florida, Miami (K.N.).

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095163 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1999 to 2001
$443k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1-TR-000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS L30 HL110027NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169
6 · The paper itself

Abstract

backgroundLimited attention has been paid to negative cardiovascular disease (CVD) risk markers despite their potential to improve medical decision making. We compared 13 negative risk markers using diagnostic likelihood ratios (DLRs), which model the change in risk for an individual after the result of an additional test. METHODS AND

resultsWe examined 6814 participants from the Multi-Ethnic Study of Atherosclerosis. Coronary artery calcium score of 0, carotid intima-media thickness <25th percentile, absence of carotid plaque, brachial flow-mediated dilation >5% change, ankle-brachial index >0.9 and <1.3, high-sensitivity C-reactive protein <2 mg/L, homocysteine <10 µmol/L, N-terminal pro-brain natriuretic peptide <100 pg/mL, no microalbuminuria, no family history of coronary heart disease (any/premature), absence of metabolic syndrome, and healthy lifestyle were compared for all and hard coronary heart disease and all CVD events over the 10-year follow-up. Models were adjusted for traditional CVD risk factors. Among all negative risk markers, coronary artery calcium score of 0 was the strongest, with an adjusted mean DLR of 0.41 (SD, 0.12) for all coronary heart disease and 0.54 (SD, 0.12) for CVD, followed by carotid intima-media thickness <25th percentile (DLR, 0.65 [SD, 0.04] and 0.75 [SD, 0.04], respectively). High-sensitivity C-reactive protein <2 mg/L and normal ankle-brachial index had DLRs >0.80. Among clinical features, absence of any family history of coronary heart disease was the strongest (DLRs, 0.76 [SD, 0.07] and 0.81 [SD, 0.06], respectively). Net reclassification improvement analyses yielded similar findings, with coronary artery calcium score of 0 resulting in the largest, most accurate downward risk reclassification.

conclusionsNegative results of atherosclerosis-imaging tests, particularly coronary artery calcium score of 0, resulted in the greatest downward shift in estimated CVD risk. These results may help guide discussions on the identification of individuals less likely to receive net benefit from lifelong preventive pharmacotherapy.

Indexed as

AgedAtherosclerosisBiomarkersCalciumCardiovascular DiseasesCohort StudiesCoronary VesselsC-Reactive ProteinEthnicityFemaleFollow-Up StudiesHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsBiomarkersCalciumC-Reactive ProteinNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)biomarkerscalciumcardiac imaging techniquescardiovascular diseasesrisk assessment

Identifiers

PMID26801055
PMCPMC4775391

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.