ArticleParasites & vectors2016
Temporal genetic diversity of Schistosoma japonicum in two endemic sites in China revealed by microsatellite markers.
Article in Parasites & vectors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Population genomic analyses of schistosome parasites highlight critical challenges facing endgame elimination efforts.Scientific reports · 2021Article
- Geographic strain differentiation of Schistosoma japonicum in the Philippines using microsatellite markers.PLoS neglected tropical diseases · 2017Article
- Genetic diversity and structure of Schistosoma japonicum within two marshland villages of Anhui, China, prior to schistosome transmission control and elimination.Parasitology research · 2017Article
- An investigation into the potential effects of infrapopulation structure and other sources of sampling error, on population genetic studies of the transmission of Schistosoma japonicum (Trematoda: Digenea).Parasites & vectors · 2016Article
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6 authors.
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Abstract
backgroundSchistosomiasis is one of the neglected tropical diseases. The causative agent of schistosomiasis in China, Schistosoma japonicum, has long been a major public health problem. An understanding of fundamental evolutionary and genetic processes in this species has major implications for its control and elimination. Intensive control efforts have greatly reduced the incidence of schistosomiasis in China, but little is known about the genetic consequences of these efforts.
methodsTo investigate this, we sampled twice (years 2003 and 2011) from two endemic regions where populations of S. japonicum had persisted despite control efforts and genotyped these samples using ten microsatellite markers. Our main hypothesis was that parasite genetic diversity would be greatly reduced across this time period.
conclusionsThere was no apparent reduction in allelic diversity, and a non-significant reduction in clonal diversity in these parasite populations between 2003 and 2011. We did, however, detect temporal genetic differentiation among the samples. Such a significant temporal genetic variation of S. japonicum populations has not been reported before.
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