ArticleBMC cardiovascular disorders2016
Differential impacts of cardiac and abdominal ectopic fat deposits on cardiometabolic risk stratification.
Article in BMC cardiovascular disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 48 citations in OpenAlex.
- Opportunistic computed tomography assessment of bone, muscle, and adipose tissue: evidence, limitations, and clinical translation.Frontiers in medicine · 2026Review
- Associations of the Triglyceride-Glucose Index and Body Fat Composition with Blood Pressure in Children and Adolescents.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Detecting severe coronary artery stenosis in T2DM patients with NAFLD using cardiac fat radiomics-based machine learning.Scientific reports · 2025Article
- Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure.Current hypertension reports · 2024Review
- Denosumab Decreases Epicardial Adipose Tissue Attenuation in Dialysis Patients with Secondary Hyperparathyroidism and Low Bone Mass.Cardiorenal medicine · 2024Article
- Serum and Adipose Dipeptidyl Peptidase 4 in Cardiovascular Surgery Patients: Influence of Dipeptidyl Peptidase 4 Inhibitors.Journal of clinical medicine · 2022Article
- Natural course of coronary artery calcium progression in Asian population with an initial score of zero.BMC cardiovascular disorders · 2020Article
- The relationship of circulating fibroblast growth factor 21 levels with pericardial fat: The Multi-Ethnic Study of Atherosclerosis.Scientific reports · 2019Article
- Is echocardiographic epicardial fat thickness increased in patients with coronary artery disease? A systematic review and meta-analysis.Electronic physician · 2018Article
- Correlations between the abdominal fat-related parameters and severity of coronary artery disease assessed by computed tomography.Quantitative imaging in medicine and surgery · 2018Article
- Morphometric measurements of systemic atherosclerosis and visceral fat: Evidence from an autopsy study.PloS one · 2017Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have shown that excessive abdominal visceral adipose tissue (AVAT) and epicardial adipose tissue (EAT) are risk factors of cardiometabolic disease; we hypothesized there is differential contribution of abdominal and cardiac fat deposits to the cardiometabolic profiles.
methodsTwo hundred eight consecutive subjects with clinical suspicion of coronary artery disease (CAD) who underwent cardiac and abdominal CT for Agatston score and abdominal visceral fat measurement were retrospectively analyzed. Regional thickness of EAT (EATth), total volume of EAT, total volume of paracardial adipose tissue (PAT) and total volume of AVAT from L2 to L5 level were measured. The relationships between abdominal and cardiac adipose tissue measurements, the number of components of metabolic syndrome, and the severity of Agatston score on a four ranking scale (0, 1-10,11-100, 101-400, >400) were investigated.
resultsThe amounts of AVAT, EAT, PAT and EATth-LAVG showed a significant linear trend with increasing number (0-5) of components in metabolic syndrome (AVAT, EAT and PAT P for trend <0.0001; EATth-LVAG P for trend <0.001). EATth at left atrioventricular groove (EATth-LAVG) showed significant linear trend with the severity of Agatston score on a four ranking scale (P for trend <0.0001). In multivariate binary regression analysis, total volume of AVAT was the sole adiposity predictor for metabolic syndrome independent to age, gender, and waist circumference (odds ratio of 1.20, 95 % CI 1.08-1.32, p < 0.001) while total volume of EAT, PAT, and EATth-LAVG were not. In contrary, EATth-LAVG was the sole adiposity predictor for Agatston score >400 (odds ratio of 1.11, 95% CI 1.034-1.184, p = 0.004).
conclusionsExcessive total volume of AVAT appears to be preferentially associated with metabolic syndrome; while EAT, esp. EATth-LAVG is preferentially associated with coronary artery disease. This differential effect of the two adiposities deserves a large-scale cohort study for further investigation.
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