Evidence map›Paper›PMID 26800862›Full record

SynthesisRhinology2016

Management of rhinosinusitis during pregnancy: systematic review and expert panel recommendations.

Devyani Lal, Ameya A Jategaonkar, Larry Borish, Linda R Chambliss, Sharon H Gnagi, Peter H Hwang, Matthew A Rank, James A Stankiewicz, Valerie J Lund

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Rhinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024).World journal of otorhinolaryngology - head and neck surgery · 2026
    Article
  4. Treatable Traits in Pregnant Women with Asthma.Respiration; international review of thoracic diseases · 2024
    Review
  5. Article
  6. Safety of intranasal corticosteroid sprays during pregnancy: an updated review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Devyani LalDepartment of Otolaryngology, Head and Neck Surgery, Mayo Clinic in Arizona, Phoenix, AZ, USA.
Ameya A JategaonkarUniversity of Arizona College of Medicine Phoenix, Phoenix, AZ, USA.
Larry BorishDepartments of Medicine and Microbiology, University of Virginia, Charlottesville, VA, USA.
Linda R ChamblissDivision of Maternal Fetal Medicine, St. Josephs Hospital and Medical Center, Phoenix, AZ, USA.
Sharon H GnagiDepartment of Otolaryngology, Head and Neck Surgery, Mayo Clinic in Arizona, Phoenix, AZ, USA.
Peter H HwangDepartment of Otolaryngology, Head and Neck Surgery, Stanford University Medical Center, Stanford, CA, USA.
Matthew A RankDivision of Allergy, Asthma, and Clinical Immunology, Mayo Clinic in Arizona, Phoenix, AZ, USA.
James A StankiewiczDepartment of Otolaryngology, Head and Neck Surgery, Loyola University Medical Center, Maywood, IL, USA.
Valerie J LundRoyal National Throat, Nose and Ear Hospital, University College London Hospitals, London, United Kingdom.
Mayo Clinic Hospital · USLoyola University Medical Center · USStanford Medicine · USSt. Joseph's Hospital and Medical Center · USUniversity College London · GBUniversity of Arizona · USUniversity of Virginia · US

Funding

Interplay between LTE4/LTE4 receptors and IFN-y with mast cells and eosinophils iR01AI057438 · NIAID · UNIVERSITY OF VIRGINIA · PI BORISH, LARRY C · 2006 to 2015
$3.7M
NIAID NIH HHS R01 AI057438
6 · The paper itself

Abstract

backgroundManagement of rhinosinusitis during pregnancy requires special considerations.

objectives1. Conduct a systematic literature review for acute and chronic rhinosinusitis (CRS) management during pregnancy. 2. Make evidence-based recommendations.

methodsThe systematic review was conducted using MEDLINE and EMBASE databases and relevant search terms. Title, abstract and full manuscript review were conducted by two authors independently. A multispecialty panel with expertise in management of Rhinological disorders, Allergy-Immunology, and Obstetrics-Gynecology was invited to review the systematic review. Recommendations were sought on use of following for CRS management during pregnancy: oral corticosteroids; antibiotics; leukotrienes; topical corticosteroid spray/irrigations/drops; aspirin desensitization; elective surgery for CRS with polyps prior to planned pregnancy; vaginal birth versus planned Caesarian for skull base erosions/ prior CSF rhinorrhea.

resultsEighty-eight manuscripts underwent full review after screening 3052 abstracts. No relevant level 1, 2, or 3 studies were found. Expert panel recommendations for rhinosinusitis management during pregnancy included continuing nasal corticosteroid sprays for CRS maintenance, using pregnancy-safe antibiotics for acute rhinosinusitis and CRS exacerbations, and discontinuing aspirin desensitization for aspirin exacerbated respiratory disease. The manuscript presents detailed recommendations.

conclusionsThe lack of evidence pertinent to managing rhinosinusitis during pregnancy warrants future trials. Expert recommendations constitute the current best available evidence.

Indexed as

Otorhinolaryngologic Surgical ProceduresAdministration, IntranasalAdrenal Cortex HormonesAnti-Bacterial AgentsCerebrospinal Fluid RhinorrheaCesarean SectionChronic DiseaseDelivery, ObstetricDisease ManagementFemaleHumansLeukotriene AntagonistsNasal PolypsParanasal SinusesPractice Guidelines as TopicPreconception CareAdrenal Cortex HormonesAnti-Bacterial AgentsLeukotriene Antagonists

Identifiers

PMID26800862
PMCPMC5797655
OpenAlexW2255842261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.