Evidence map›Paper›PMID 26800789›Full record

ArticleJMIR research protocols2016

HEART Pathway Accelerated Diagnostic Protocol Implementation: Prospective Pre-Post Interrupted Time Series Design and Methods.

Simon A Mahler, Gregory L Burke, Pamela W Duncan, Larry D Case, David M Herrington, Robert F Riley, Brian J Wells, Brian C Hiestand, Chadwick D Miller

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in JMIR research protocols, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02056964 completednot on this map

The HEART Pathway: Bridging the Gap Between Operations, Research, and Education

TypeobservationalSponsorWake Forest University Health SciencesRan2013 to 2019Enrolled14,717ConditionsChest Pain, Acute Coronary Syndrome, Chest Pain Atypical Syndrome, Chest Pain Rule Out Myocardial Infarction
NCT07074808 phase4completednot on this mapstarted 2022, after this paper: background citation

HRV Guided Accelerated Diagnostic Protocol for Chest Pain Patients - Randomised Control Trial (HRV-ADP RCT)

TypeinterventionalSponsorSingapore General HospitalRan2022 to 2025Enrolled1,120ConditionsChest Pain, EmergenciesArmsaiTriage risk score
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Rural and socioeconomic differences in the effectiveness of the HEART Pathway accelerated diagnostic protocol.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2023
    Article
  4. Article
  5. Major adverse cardiac event rates in moderate-risk patients: Does prior coronary disease matter?Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2022
    Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Chest pain triage: Current trends in the emergency departments in the United States.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Review
  16. The HEART Pathway and Hospital Cost Savings.Critical pathways in cardiology · 2017
    Article
  17. Syncope Risk Stratification in the Emergency Department: Another Step Forward.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2016
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Simon A MahlerWake Forest School of Medicine, Department of Emergency Medicine, Winston Salem, NC, United States. smahler@wakehealth.edu.ORCID http://orcid.org/0000-0003-2199-4078
Wake Forest University · US

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
CMR-IMPACTR01HL118263 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MILLER, CHADWICK DAVID · 2013 to 2018
$3.7M
NCATS NIH HHS UL1 TR001420NHLBI NIH HHS L30 HL120008NHLBI NIH HHS R01 HL118263
6 · The paper itself

Abstract

backgroundMost patients presenting to US Emergency Departments (ED) with chest pain are hospitalized for comprehensive testing. These evaluations cost the US health system >$10 billion annually, but have a diagnostic yield for acute coronary syndrome (ACS) of <10%. The history/ECG/age/risk factors/troponin (HEART) Pathway is an accelerated diagnostic protocol (ADP), designed to improve care for patients with acute chest pain by identifying patients for early ED discharge. Prior efficacy studies demonstrate that the HEART Pathway safely reduces cardiac testing, while maintaining an acceptably low adverse event rate.

objectiveThe purpose of this study is to determine the effectiveness of HEART Pathway ADP implementation within a health system.

methodsThis controlled before-after study will accrue adult patients with acute chest pain, but without ST-segment elevation myocardial infarction on electrocardiogram for two years and is expected to include approximately 10,000 patients. Outcomes measures include hospitalization rate, objective cardiac testing rates (stress testing and angiography), length of stay, and rates of recurrent cardiac care for participants.

resultsIn pilot data, the HEART Pathway decreased hospitalizations by 21%, decreased hospital length (median of 12 hour reduction), without increasing adverse events or recurrent care. At the writing of this paper, data has been collected on >5000 patient encounters. The HEART Pathway has been fully integrated into health system electronic medical records, providing real-time decision support to our providers.

conclusionsWe hypothesize that the HEART Pathway will safely reduce healthcare utilization. This study could provide a model for delivering high-value care to the 8-10 million US ED patients with acute chest pain each year. CLINICALTRIAL: Clinicaltrials.gov NCT02056964; https://clinicaltrials.gov/ct2/show/NCT02056964 (Archived by WebCite at http://www.webcitation.org/6ccajsgyu).

Indexed as

acute coronary syndromechest paindecision support techniqueelectronic medical recordsimplementation methodsinterrupted time series analysis

Identifiers

PMID26800789
PMCPMC4744329
OpenAlexW2273855524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.